GGTL3

Gamma-glutamyltransferase 7

Identifiers

GGT7; D20S101; GGT4; GGTL3; GGTL5; dJ18C9.2

External IDs

OMIM: 612342 MGI: 1913385 HomoloGene: 70866 GeneCards: GGT7 Gene

2.3.2.2

Gene Ontology
Molecular function	• gamma-glutamyltransferase activity • acyltransferase activity • transferase activity
Cellular component	• membrane • integral to membrane
Biological process	• glutathione biosynthetic process
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 20:
33.43 – 33.46 Mb

Chr 2:
155.32 – 155.34 Mb

PubMed search

[1]

[2]

Gamma-glutamyltransferase 7 is an enzyme that in humans is encoded by the GGT7 gene.^[1]^[2]^[3]

Gamma-glutamyltransferase is a membrane-associated protein involved in both the metabolism of glutathione and in the transpeptidation of amino acids. Changes in the activity of gamma-glutamyltransferase may signal preneoplastic or toxic conditions in the liver or kidney. The protein encoded by this gene is similar in sequence to gamma-glutamyltransferase, but its function is unknown.^[3]

References

^ Figlewicz DA, Delattre O, Guellaen G, Krizus A, Thomas G, Zucman J, Rouleau GA (Oct 1993). "Mapping of human gamma-glutamyl transpeptidase genes on chromosome 22 and other human autosomes". Genomics 17 (2): 299–305. doi:10.1006/geno.1993.1325. PMID 8104871.
^ Heisterkamp N, Groffen J, Warburton D, Sneddon TP (Apr 2008). "The human gamma-glutamyltransferase gene family". Hum Genet 123 (4): 321–32. doi:10.1007/s00439-008-0487-7. PMID 18357469.
^ ^a ^b "Entrez Gene: GGTL3 gamma-glutamyltransferase-like 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2686.

Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Jikuya H, Takano J, Kikuno R, et al. (2003). "Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones.". DNA Res. 10 (1): 49–57. doi:10.1093/dnares/10.1.49. PMID 12693554.
Llamazares M, Cal S, Quesada V, López-Otín C (2003). "Identification and characterization of ADAMTS-20 defines a novel subfamily of metalloproteinases-disintegrins with multiple thrombospondin-1 repeats and a unique GON domain.". J. Biol. Chem. 278 (15): 13382–9. doi:10.1074/jbc.M211900200. PMID 12562771.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
He X, Di Y, Li J, et al. (2002). "Molecular cloning and characterization of CT120, a novel membrane-associated gene involved in amino acid transport and glutathione metabolism.". Biochem. Biophys. Res. Commun. 297 (3): 528–36. doi:10.1016/S0006-291X(02)02227-1. PMID 12270127.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.

GGTL3

References

Further reading