GGA2
ADP-ribosylation factor-binding protein GGA2 is a protein that in humans is encoded by the GGA2 gene.[1][2][3]
This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. This family member may play a significant role in cargo molecules regulation and clathrin-coated vesicle assembly.[3]
Interactions
GGA2 has been shown to interact with RABEP1,[4] Sortilin 1,[5][6] BACE2[7] and CLINT1.[8][9]
References
- ^ Hirst J, Lui WW, Bright NA, Totty N, Seaman MN, Robinson MS (May 2000). "A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome". J Cell Biol 149 (1): 67–80. doi:10.1083/jcb.149.1.67. PMC 2175106. PMID 10747088. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2175106.
- ^ Boman AL, Zhang C, Zhu X, Kahn RA (Jul 2000). "A family of ADP-ribosylation factor effectors that can alter membrane transport through the trans-Golgi". Mol Biol Cell 11 (4): 1241–55. PMC 14844. PMID 10749927. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=14844.
- ^ a b "Entrez Gene: GGA2 golgi associated, gamma adaptin ear containing, ARF binding protein 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23062.
- ^ Mattera, Rafael; Arighi Cecilia N, Lodge Robert, Zerial Marino, Bonifacino Juan S (Jan. 2003). "Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex". EMBO J. (England) 22 (1): 78–88. doi:10.1093/emboj/cdg015. ISSN 0261-4189. PMC 140067. PMID 12505986. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=140067.
- ^ Nielsen, M S; Madsen P, Christensen E I, Nykjaer A, Gliemann J, Kasper D, Pohlmann R, Petersen C M (May. 2001). "The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein". EMBO J. (England) 20 (9): 2180–90. doi:10.1093/emboj/20.9.2180. ISSN 0261-4189. PMC 125444. PMID 11331584. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=125444.
- ^ Jacobsen, Linda; Madsen Peder, Nielsen Morten S, Geraerts Wijnand P M, Gliemann Jørgen, Smit August B, Petersen Claus M (Jan. 2002). "The sorLA cytoplasmic domain interacts with GGA1 and -2 and defines minimum requirements for GGA binding". FEBS Lett. (Netherlands) 511 (1–3): 155–8. doi:10.1016/S0014-5793(01)03299-9. ISSN 0014-5793. PMID 11821067.
- ^ He, Xiangyuan; Chang Wan-Pin, Koelsch Gerald, Tang Jordan (Jul. 2002). "Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2". FEBS Lett. (Netherlands) 524 (1–3): 183–7. doi:10.1016/S0014-5793(02)03052-1. ISSN 0014-5793. PMID 12135764.
- ^ Wasiak, Sylwia; Legendre-Guillemin Valerie, Puertollano Rosa, Blondeau Francois, Girard Martine, de Heuvel Elaine, Boismenu Daniel, Bell Alexander W, Bonifacino Juan S, McPherson Peter S (Sep. 2002). "Enthoprotin: a novel clathrin-associated protein identified through subcellular proteomics". J. Cell Biol. (United States) 158 (5): 855–62. doi:10.1083/jcb.200205078. ISSN 0021-9525. PMC 2173151. PMID 12213833. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2173151.
- ^ Kalthoff, Christoph; Groos Stephanie, Kohl Rüdiger, Mahrhold Stefan, Ungewickell Ernst J (Nov. 2002). "Clint: a novel clathrin-binding ENTH-domain protein at the Golgi". Mol. Biol. Cell (United States) 13 (11): 4060–73. doi:10.1091/mbc.E02-03-0171. ISSN 1059-1524. PMC 133614. PMID 12429846. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=133614.
Further reading
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Kikuno R, Nagase T, Ishikawa K, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
- Loftus BJ, Kim UJ, Sneddon VP, et al. (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.
- Poussu A, Lohi O, Lehto VP (2000). "Vear, a novel Golgi-associated protein with VHS and gamma-adaptin "ear" domains". J. Biol. Chem. 275 (10): 7176–83. doi:10.1074/jbc.275.10.7176. PMID 10702286.
- Dell'Angelica EC, Puertollano R, Mullins C, et al. (2000). "GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex". J. Cell Biol. 149 (1): 81–94. doi:10.1083/jcb.149.1.81. PMC 2175099. PMID 10747089. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2175099.
- Takatsu H, Yoshino K, Nakayama K (2000). "Adaptor gamma ear homology domain conserved in gamma-adaptin and GGA proteins that interact with gamma-synergin". Biochem. Biophys. Res. Commun. 271 (3): 719–25. doi:10.1006/bbrc.2000.2700. PMID 10814529.
- Puertollano R, Randazzo PA, Presley JF, et al. (2001). "The GGAs promote ARF-dependent recruitment of clathrin to the TGN". Cell 105 (1): 93–102. doi:10.1016/S0092-8674(01)00299-9. PMID 11301005.
- Nielsen MS, Madsen P, Christensen EI, et al. (2001). "The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein". EMBO J. 20 (9): 2180–90. doi:10.1093/emboj/20.9.2180. PMC 125444. PMID 11331584. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=125444.
- Puertollano R, Aguilar RC, Gorshkova I, et al. (2001). "Sorting of mannose 6-phosphate receptors mediated by the GGAs". Science 292 (5522): 1712–6. doi:10.1126/science.1060750. PMID 11387475.
- Zhu Y, Doray B, Poussu A, et al. (2001). "Binding of GGA2 to the lysosomal enzyme sorting motif of the mannose 6-phosphate receptor". Science 292 (5522): 1716–8. doi:10.1126/science.1060896. PMID 11387476.
- Takatsu H, Katoh Y, Shiba Y, Nakayama K (2001). "Golgi-localizing, gamma-adaptin ear homology domain, ADP-ribosylation factor-binding (GGA) proteins interact with acidic dileucine sequences within the cytoplasmic domains of sorting receptors through their Vps27p/Hrs/STAM (VHS) domains". J. Biol. Chem. 276 (30): 28541–5. doi:10.1074/jbc.C100218200. PMID 11390366.
- Jacobsen L, Madsen P, Nielsen MS, et al. (2002). "The sorLA cytoplasmic domain interacts with GGA1 and -2 and defines minimum requirements for GGA binding". FEBS Lett. 511 (1–3): 155–8. doi:10.1016/S0014-5793(01)03299-9. PMID 11821067.
- Doray B, Bruns K, Ghosh P, Kornfeld S (2002). "Interaction of the cation-dependent mannose 6-phosphate receptor with GGA proteins". J. Biol. Chem. 277 (21): 18477–82. doi:10.1074/jbc.M201879200. PMID 11886874.
- Takatsu H, Yoshino K, Toda K, Nakayama K (2002). "GGA proteins associate with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors". Biochem. J. 365 (Pt 2): 369–78. doi:10.1042/BJ20020428. PMC 1222692. PMID 11950392. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1222692.
- He X, Chang WP, Koelsch G, Tang J (2002). "Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2". FEBS Lett. 524 (1–3): 183–7. doi:10.1016/S0014-5793(02)03052-1. PMID 12135764.
- Wasiak S, Legendre-Guillemin V, Puertollano R, et al. (2002). "Enthoprotin: a novel clathrin-associated protein identified through subcellular proteomics". J. Cell Biol. 158 (5): 855–62. doi:10.1083/jcb.200205078. PMC 2173151. PMID 12213833. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2173151.
- Kalthoff C, Groos S, Kohl R, et al. (2003). "Clint: a novel clathrin-binding ENTH-domain protein at the Golgi". Mol. Biol. Cell 13 (11): 4060–73. doi:10.1091/mbc.E02-03-0171. PMC 133614. PMID 12429846. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=133614.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
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PDB gallery
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1mhq: Crystal Structure Of Human GGA2 VHS Domain
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