GFRA2 (gene)
GDNF family receptor alpha-2 is a protein that in humans is encoded by the GFRA2 gene.[1][2]
Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases.[2]
Interactions
GFRA2 (gene) has been shown to interact with Glial cell line-derived neurotrophic factor.[3][4]
References
- ^ Sanicola M, Hession C, Worley D, Carmillo P, Ehrenfels C, Walus L, Robinson S, Jaworski G, Wei H, Tizard R, Whitty A, Pepinsky RB, Cate RL (Jul 1997). "Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins". Proc Natl Acad Sci U S A 94 (12): 6238–43. doi:10.1073/pnas.94.12.6238. PMC 21033. PMID 9177201. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=21033.
- ^ a b "Entrez Gene: GFRA2 GDNF family receptor alpha 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2675.
- ^ Jing, S; Yu Y, Fang M, Hu Z, Holst P L, Boone T, Delaney J, Schultz H, Zhou R, Fox G M (Dec. 1997). "GFRalpha-2 and GFRalpha-3 are two new receptors for ligands of the GDNF family". J. Biol. Chem. (UNITED STATES) 272 (52): 33111–7. doi:10.1074/jbc.272.52.33111. ISSN 0021-9258. PMID 9407096.
- ^ Cik, M; Masure S, Lesage A S, Van Der Linden I, Van Gompel P, Pangalos M N, Gordon R D, Leysen J E (Sep. 2000). "Binding of GDNF and neurturin to human GDNF family receptor alpha 1 and 2. Influence of cRET and cooperative interactions". J. Biol. Chem. (UNITED STATES) 275 (36): 27505–12. doi:10.1074/jbc.M000306200. ISSN 0021-9258. PMID 10829012.
Further reading
- Baloh RH, Tansey MG, Golden JP et al. (1997). "TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret". Neuron 18 (5): 793–802. doi:10.1016/S0896-6273(00)80318-9. PMID 9182803.
- Klein RD, Sherman D, Ho WH et al. (1997). "A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor". Nature 387 (6634): 717–21. doi:10.1038/42722. PMID 9192898.
- Suvanto P, Wartiovaara K, Lindahl M et al. (1997). "Cloning, mRNA distribution and chromosomal localisation of the gene for glial cell line-derived neurotrophic factor receptor beta, a homologue to GDNFR-alpha". Hum. Mol. Genet. 6 (8): 1267–73. doi:10.1093/hmg/6.8.1267. PMID 9259272.
- Jing S, Yu Y, Fang M et al. (1998). "GFRalpha-2 and GFRalpha-3 are two new receptors for ligands of the GDNF family". J. Biol. Chem. 272 (52): 33111–7. doi:10.1074/jbc.272.52.33111. PMID 9407096.
- Tansey MG, Baloh RH, Milbrandt J, Johnson EM (2000). "GFRalpha-mediated localization of RET to lipid rafts is required for effective downstream signaling, differentiation, and neuronal survival". Neuron 25 (3): 611–23. doi:10.1016/S0896-6273(00)81064-8. PMID 10774729.
- Cik M, Masure S, Lesage AS et al. (2000). "Binding of GDNF and neurturin to human GDNF family receptor alpha 1 and 2. Influence of cRET and cooperative interactions". J. Biol. Chem. 275 (36): 27505–12. doi:10.1074/jbc.M000306200. PMID 10829012.
- Vanhorne JB, Gimm O, Myers SM et al. (2001). "Cloning and characterization of the human GFRA2 locus and investigation of the gene in Hirschsprung disease". Hum. Genet. 108 (5): 409–15. doi:10.1007/s004390100506. PMID 11409869.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Yoong LF, Too HP (2007). "Glial cell line-derived neurotrophic factor and neurturin inhibit neurite outgrowth and activate RhoA through GFR alpha 2b, an alternatively spliced isoform of GFR alpha 2". J. Neurosci. 27 (21): 5603–14. doi:10.1523/JNEUROSCI.4552-06.2007. PMID 17522305.