GEFT

Rho guanine nucleotide exchange factor (GEF) 25

Identifiers

ARHGEF25; GEFT; p63RhoGEF

External IDs

OMIM: 610215 MGI: 1277173 HomoloGene: 32691 GeneCards: ARHGEF25 Gene

Gene Ontology
Molecular function	• guanyl-nucleotide exchange factor activity • Rho guanyl-nucleotide exchange factor activity
Cellular component	• intracellular • cytoplasm • cytosol • plasma membrane • myofibril • sarcomere
Biological process	• regulation of Rho protein signal transduction
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 12:
58 – 58.02 Mb

Chr 10:
126.62 – 126.63 Mb

PubMed search

[1]

[2]

RAC/CDC42 exchange factor, also known as GEFT, is a human gene.^[1]

Interactions

GEFT has been shown to interact with RHOA.^[2]

References

^ "Entrez Gene: GEFT RAC/CDC42 exchange factor". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=115557.
^ Lutz, Susanne; Freichel-Blomquist Andrea, Rümenapp Ulrich, Schmidt Martina, Jakobs Karl H, Wieland Thomas (May. 2004). "p63RhoGEF and GEFT are Rho-specific guanine nucleotide exchange factors encoded by the same gene". Naunyn Schmiedebergs Arch. Pharmacol. (Germany) 369 (5): 540–6. doi:10.1007/s00210-004-0926-5. ISSN 0028-1298. PMID 15069594.

Lutz S, Shankaranarayanan A, Coco C, et al. (2008). "Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs.". Science 318 (5858): 1923–7. doi:10.1126/science.1147554. PMID 18096806.
Bryan BA, Cai Y, Liu M (2006). "The Rho-family guanine nucleotide exchange factor GEFT enhances retinoic acid- and cAMP-induced neurite outgrowth.". J. Neurosci. Res. 83 (7): 1151–9. doi:10.1002/jnr.20814. PMID 16496360.
Bryan BA, Mitchell DC, Zhao L, et al. (2006). "Modulation of muscle regeneration, myogenesis, and adipogenesis by the Rho family guanine nucleotide exchange factor GEFT.". Mol. Cell. Biol. 25 (24): 11089–101. doi:10.1128/MCB.25.24.11089-11101.2005. PMC 1316953. PMID 16314529. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1316953.
Lutz S, Freichel-Blomquist A, Yang Y, et al. (2005). "The guanine nucleotide exchange factor p63RhoGEF, a specific link between Gq/11-coupled receptor signaling and RhoA.". J. Biol. Chem. 280 (12): 11134–9. doi:10.1074/jbc.M411322200. PMID 15632174.
Bryan B, Kumar V, Stafford LJ, et al. (2004). "GEFT, a Rho family guanine nucleotide exchange factor, regulates neurite outgrowth and dendritic spine formation.". J. Biol. Chem. 279 (44): 45824–32. doi:10.1074/jbc.M406216200. PMID 15322108.
Lutz S, Freichel-Blomquist A, Rümenapp U, et al. (2004). "p63RhoGEF and GEFT are Rho-specific guanine nucleotide exchange factors encoded by the same gene.". Naunyn Schmiedebergs Arch. Pharmacol. 369 (5): 540–6. doi:10.1007/s00210-004-0926-5. PMID 15069594.
Guo X, Stafford LJ, Bryan B, et al. (2003). "A Rac/Cdc42-specific exchange factor, GEFT, induces cell proliferation, transformation, and migration.". J. Biol. Chem. 278 (15): 13207–15. doi:10.1074/jbc.M208896200. PMID 12547822.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Souchet M, Portales-Casamar E, Mazurais D, et al. (2002). "Human p63RhoGEF, a novel RhoA-specific guanine nucleotide exchange factor, is localized in cardiac sarcomere.". J. Cell. Sci. 115 (Pt 3): 629–40. PMID 11861769.

GEFT

Interactions

References

Further reading