GAL3ST1

Galactose-3-O-sulfotransferase 1

Identifiers

External IDs

OMIM: 602300 MGI: 1858277 HomoloGene: 3574 GeneCards: GAL3ST1 Gene

2.8.2.11

Gene Ontology
Molecular function	• galactosylceramide sulfotransferase activity • sulfotransferase activity • transferase activity
Cellular component	• Golgi membrane • membrane fraction • Golgi apparatus • integral to plasma membrane • membrane
Biological process	• protein N-linked glycosylation • galactosylceramide biosynthetic process • spermatogenesis • biosynthetic process • myelination
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 22:
30.95 – 30.97 Mb

Chr 11:
3.88 – 3.9 Mb

PubMed search

[1]

[2]

Galactosylceramide sulfotransferase is an enzyme that in humans is encoded by the GAL3ST1 gene.^[1]^[2]^[3]

Sulfonation, an important step in the metabolism of many drugs, xenobiotics, hormones, and neurotransmitters, is catalyzed by sulfotransferases. The product of this gene is galactosylceramide sulfotransferase which catalyzes the conversion between 3'-phosphoadenylylsulfate + a galactosylceramide to adenosine 3',5'-bisphosphate + galactosylceramide sulfate. Activity of this sulfotransferase is enhanced in renal cell carcinoma.^[3]

References

^ "Toward a complete human genome sequence". Genome Res 8 (11): 1097–108. Jan 1999. doi:10.1101/gr.8.11.1097. PMID 9847074.
^ Honke K, Tsuda M, Hirahara Y, Ishii A, Makita A, Wada Y (Apr 1997). "Molecular cloning and expression of cDNA encoding human 3'-phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase". J Biol Chem 272 (8): 4864–8. doi:10.1074/jbc.272.8.4864. PMID 9030544.
^ ^a ^b "Entrez Gene: GAL3ST1 galactose-3-O-sulfotransferase 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9514.

Siegrist HP, Jutzi H, Steck AJ et al. (1977). "Age-dependent modulation of 3'-phosphoadenosine-5'-phosphosulfate-galactosylceramide sulfotransferase by lipids extracted from the microsomal membranes and artificial lipid mixtures". Biochim. Biophys. Acta 489 (1): 58–63. PMID 911873.
Stein C, Gieselmann V, Kreysing J et al. (1989). "Cloning and expression of human arylsulfatase A". J. Biol. Chem. 264 (2): 1252–9. PMID 2562955.
Fleischer B, Zambrano F (1973). "Localization of cerebroside-sulfotransferase activity in the Golgi apparatus of rat kidney". Biochem. Biophys. Res. Commun. 52 (3): 951–8. doi:10.1016/0006-291X(73)91029-2. PMID 4710574.
Farrell DF, McKhann GM (1971). "Characterization of cerebroside sulfotransferase from rat brain". J. Biol. Chem. 246 (15): 4694–702. PMID 5562350.
Costantino-Ceccarini E, Waehneldt TV, Ginalski H et al. (1982). "Distribution of lipid synthesizing enzymes, 2',3'-cyclic nucleotide 3'-phosphodiesterase, and myelin proteins in rat forebrain subfractions during development". Neurochem. Res. 7 (1): 1–12. doi:10.1007/BF00965064. PMID 6280086.
Benjamins JA, Hadden T, Skoff RP (1982). "Cerebroside sulfotransferase in Golgi-enriched fractions from rat brain". J. Neurochem. 38 (1): 233–41. doi:10.1111/j.1471-4159.1982.tb10875.x. PMID 6955451.
Honke K, Yamane M, Ishii A et al. (1996). "Purification and characterization of 3'-phosphoadenosine-5'-phosphosulfate:GalCer sulfotransferase from human renal cancer cells". J. Biochem. 119 (3): 421–7. PMID 8830034.
Tsuda M, Egashira M, Niikawa N et al. (2000). "Cancer-associated alternative usage of multiple promoters of human GalCer sulfotransferase gene". Eur. J. Biochem. 267 (9): 2672–9. doi:10.1046/j.1432-1327.2000.01281.x. PMID 10785389.
Eckhardt M, Fewou SN, Ackermann I, Gieselmann V (2002). "N-glycosylation is required for full enzymic activity of the murine galactosylceramide sulphotransferase". Biochem. J. 368 (Pt 1): 317–24. doi:10.1042/BJ20020946. PMC 1222978. PMID 12175333. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1222978.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Collins JE, Wright CL, Edwards CA et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=545604.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.

GAL3ST1

References

Further reading