GABPA

GA binding protein transcription factor, alpha subunit 60kDa

PDB rendering based on 1awc.
Identifiers
Symbols GABPA; E4TF1-60; E4TF1A; NFT2; NRF2; NRF2A
External IDs OMIM: 600609 MGI: 95610 HomoloGene: 1543 GeneCards: GABPA Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 2551 14390
Ensembl ENSG00000154727 ENSMUSG00000008976
UniProt Q06546 Q6HAA1
RefSeq (mRNA) NM_001197297.1 NM_008065.2
RefSeq (protein) NP_001184226.1 NP_032091.2
Location (UCSC) Chr 21:
27.11 – 27.14 Mb		 Chr 16:
84.84 – 84.86 Mb
PubMed search [1] [2]

GA-binding protein alpha chain is a protein that in humans is encoded by the GABPA gene.[1]

This gene encodes one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is likely involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. This subunit also shares identity with a subunit constituting the transcription factor E4TF1, responsible for expression of the adenovirus E4 gene. Because of its chromosomal localization and ability to form heterodimers with other polypeptides, this gene may play a role in the Down Syndrome phenotype.[2]

Contents

Interactions

GABPA has been shown to interact with Host cell factor C1,[3] Sp1 transcription factor[4] and Sp3 transcription factor.[4]

References

  1. ^ Watanabe H, Sawada J, Yano K, Yamaguchi K, Goto M, Handa H (April 1993). "cDNA cloning of transcription factor E4TF1 subunits with Ets and notch motifs". Mol Cell Biol 13 (3): 1385–91. PMC 359448. PMID 8441384. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=359448. 
  2. ^ "Entrez Gene: GABPA GA binding protein transcription factor, alpha subunit 60kDa". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2551. 
  3. ^ Vogel, J L; Kristie T M (February 2000). "The novel coactivator C1 (HCF) coordinates multiprotein enhancer formation and mediates transcription activation by GABP". EMBO J. (ENGLAND) 19 (4): 683–90. doi:10.1093/emboj/19.4.683. ISSN 0261-4189. PMC 305606. PMID 10675337. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=305606. 
  4. ^ a b Galvagni, F; Capo S, Oliviero S (March 2001). "Sp1 and Sp3 physically interact and co-operate with GABP for the activation of the utrophin promoter". J. Mol. Biol. (England) 306 (5): 985–96. doi:10.1006/jmbi.2000.4335. ISSN 0022-2836. PMID 11237613. 

Further reading

External links