gamma-aminobutyric acid (GABA) B receptor, 1 | |
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Identifiers | |
Symbol | GABBR1 |
Entrez | 2550 |
HUGO | 4070 |
OMIM | 603540 |
RefSeq | NM_021905 |
UniProt | Q9UBS5 |
Other data | |
Locus | Chr. 6 p21.3 |
gamma-aminobutyric acid (GABA) B receptor, 2 | |
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Identifiers | |
Symbol | GABBR2 |
Alt. symbols | GPR51 |
Entrez | 9568 |
HUGO | 4507 |
OMIM | 607340 |
RefSeq | NM_005458 |
UniProt | O75899 |
Other data | |
Locus | Chr. 9 q22.1-22.3 |
GABAB receptors (GABABR) are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA) that are linked via G-proteins to potassium channels.[1] These receptors are found in the central and peripheral autonomic nervous system.
Contents |
They can stimulate the opening of K+ channels which brings the neuron closer to the equilibrium potential of K+, hyperpolarising the neuron. This prevents sodium channels from opening, action potentials from firing, and VDCCs from opening, and so stops neurotransmitter release. Thus GABAB receptors are considered inhibitory receptors.
GABAB receptors can also reduce the activity of adenylyl cyclase and decrease the cell’s conductance to Ca2+.
GABAB receptors are involved in behavioral actions of ethanol,[2] gamma-Hydroxybutyric acid (GHB),[3] and possibly in pain.[4] Recent research suggests that these receptors may play an important developmental role.[5]
GABABRs are similar in structure to and in the same receptor family with metabotropic glutamate receptors.[6] There are two subtypes of the receptor, GABAB1 and GABAB2,[7] and these appear to assemble as heterodimers in neuronal membranes by linking up by their intracellular C termini.[6]
It is speculated that binding of GABA causes the subunits to swing shut around the agonist like a venus fly trap.