Ftx (gene)

Identifiers
Symbol [1]
External IDs OMIM: 300331 GeneCards: Gene
Orthologs
Species Human Mouse
Entrez 84434 n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search [2] n/a

In molecular biology, FTX transcript, XIST regulator (non-protein coding), also known as FTX (Five prime to Xist), is a long non-coding RNA. In humans, it is located on the X chromosome. It was identified during sequence analysis of the X inactivation centre, surrounding the XIST gene.[1] FTX contains several microRNAs within its introns.[2] It upregulates expression of XIST, and inhibits DNA methylation of the XIST promoter. [2]

See also

References

  1. ^ Chureau C, Prissette M, Bourdet A, Barbe V, Cattolico L, Jones L et al. (2002). "Comparative sequence analysis of the X-inactivation center region in mouse, human, and bovine.". Genome Res 12 (6): 894–908. doi:10.1101/gr.152902. PMC 1383731. PMID 12045143. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1383731. 
  2. ^ a b Chureau C, Chantalat S, Romito A, Galvani A, Duret L, Avner P et al. (2011). "Ftx is a non-coding RNA which affects Xist expression and chromatin structure within the X-inactivation center region.". Hum Mol Genet 20 (4): 705–18. doi:10.1093/hmg/ddq516. PMID 21118898. http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21118898.