Flusilazole

Flusilazole
IUPAC name

1-((bis(4-fluorophenyl)methylsilyl)methyl)-1H-1,2,4-triazole
Other names

DPX-H6573;
Identifiers
CAS number 85509-19-9
PubChem 73675
Jmol-3D images Image 1
Properties
Molecular formula C16H15F2N3Si
Density 315.392 g/cm3
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Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Flusilazole (DPX-H6573) is an organosilicon fungicide invented by DuPont, which is used to control fungal infections on a variety of fruit and vegetable crops.[1][2][3] It is moderately toxic to animals and has been shown to produce birth defects and embryotoxicity at high doses.[4][5]

Reference

  1. ^ Moberg, W. K.; Basarab, G. S.; Cuomo, J.; Liang, P. H. (1987). Biologically Active Organosilicon Compounds. 355. pp. 288. doi:10.1021/bk-1987-0355.ch026.  edit
  2. ^ Bostanian NJ, Larocque N, Chouinard G, Coderre D (November 2001). "Baseline toxicity of several pesticides to Hyaliodes vitripennis (Say) (Hemiptera: Miridae)". Pest Management Science 57 (11): 1007–10. doi:10.1002/ps.374. PMID 11721516. 
  3. ^ Eckert MR, Rossall S, Selley A, Fitt BD (April 2010). "Effects of fungicides on in vitro spore germination and mycelial growth of the phytopathogens Leptosphaeria maculans and L. biglobosa (phoma stem canker of oilseed rape)". Pest Management Science 66 (4): 396–405. doi:10.1002/ps.1890. PMID 20013877. 
  4. ^ Farag AT, Ibrahim HH (February 2007). "Developmental toxic effects of antifungal flusilazole administered by gavage to mice". Birth Defects Research. Part B, Developmental and Reproductive Toxicology 80 (1): 12–7. doi:10.1002/bdrb.20098. PMID 17187383. 
  5. ^ Hermsen SA, van den Brandhof EJ, van der Ven LT, Piersma AH (January 2011). "Relative embryotoxicity of two classes of chemicals in a modified zebrafish embryotoxicity test and comparison with their in vivo potencies". Toxicology in Vitro : an International Journal Published in Association with BIBRA 25 (3): 745–753. doi:10.1016/j.tiv.2011.01.005. PMID 21238576.