Fludroxycortide

Fludroxycortide

Systematic (IUPAC) name
6-fluoro-11,21 dihydroxy-16,17- [(l-methylethylidene) bis (oxy)]-, (6?, 11?, 16?)- Pregn-4-ene-3,20-dione
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy cat.	?
Legal status	POM (UK)
Identifiers
CAS number	1524-88-5^Y
ATC code	D07AC07
PubChem	CID 15209
DrugBank	APRD00982
ChemSpider	14475^Y
UNII	8EUL29XUQT^Y
KEGG	D00328^Y
ChEMBL	CHEMBL1201012^N
Chemical data
Formula	C₂₄H₃₃F O₆
Mol. mass	436.514 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C24H33FO6/c1-21(2)30-19-9-14-13-8-16(25)15-7-12(27)5-6-22(15,3)20(13)17(28)10-23(14,4)24(19,31-21)18(29)11-26/h7,13-14,16-17,19-20,26,28H,5-6,8-11H2,1-4H3/t13-,14-,16-,17-,19+,20+,22-,23-,24+/m0/s1^Y Key:POPFMWWJOGLOIF-XWCQMRHXSA-N^Y
N(what is this?) (verify)

Fludroxycortide (INN; also known as flurandrenolone or flurandrenolide ) is a synthetic steroid and is used as an anti-inflammatory treatment for use on skin irritations.

Licensed indications in the United Kingdom include "recalcitrant dermatoses".

Fludroxycortide is available in ointment, cream and as an impregnated blenderm tape. (Haelan tape (Typharm Ltd), Cordran tape)

References

Corticosteroids – glucocorticoids and mineralocorticoids (H02)
(also A07EA, C05AA, D07, D10AA, R01AD, R03BA, S01BA, S02B, and S03B)

Mineralocorticoids
(3-one, 4-ene,
no FG at 16)

Pregnenedione: ALDOSTERONE • 11-DEOXYCORTICOSTERONE • HALOGENATED AT 9: Fludrocortisone

Glucocorticoids
(3-one, 4-ene,
11-FG,
17-hydroxy)

Pregnene	CORTISONE

Pregnenedione (+20-one)	HYDROCORTISONE/CORTISOL^# (Hydrocortisone aceponate, Hydrocortisone buteprate, Hydrocortisone butyrate) • Budesonide • Ciclesonide • Deflazacort • Medrysone • Tixocortol • HALOGENATED AT 6: Cloprednol • HALOGENATED, WITH FG AT 16: Halcinonide

Pregnadiene (+1-ene)	Rimexolone • HALOGENATED, WITH FG AT 16: Flunisolide • Triamcinolone • Amcinonide • Fluocinolone acetonide (Fluocinonide)

Pregnadienediol (+21-hydroxy)	Prednisone (Meprednisone) • HALOGENATED AT 9: Fluorometholone • HALOGENATED, WITH FG AT 16: Fluocortolone (Clocortolone, Diflucortolone, Fluocortin) • Desoximetasone

Pregnadienetriol (+11-hydroxy)	Prednisolone^# (Methylprednisolone, Methylprednisolone aceponate, Prednicarbate, Prednylidene) • Desonide • HALOGENATED: Fluprednisolone (Difluprednate, Fluperolone) • HALOGENATED, WITH FG AT 16: Dexamethasone^# • Betamethasone (Clobetasol, Clobetasone, Diflorasone, Halometasone, Ulobetasol) • Beclometasone • Paramethasone • Alclometasone • Fluclorolone • Flumetasone • Fluprednidene

Pregnatriene (+2-ene)	Cortivazol

Androstene	HALOGENATED, WITH FG AT 16: Fluticasone (Fluticasone propionate, Fluticasone furoate)

Other/ungrouped	HALOGENATED: Loteprednol • HALOGENATED, WITH FG AT 16: Fludroxycortide • Formocortal • Mometasone furoate

Aldosterone antagonists

Spironolactone • Eplerenone • Potassium canrenoate • Canrenone

Synthesis modifiers

Trilostane • Carbenoxolone • Aminoglutethimide • Metyrapone

^#WHO-EM. ^‡Withdrawn from market. Clinical trials: ^†Phase III. ^§Never to phase III

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