Fibrosis

Fibrosis
Classification and external resources

Micrograph of a heart showing fibrosis (yellow - left of image) and amyloid deposition (brown - right of image). Movat's stain.
MeSH D005355

Fibrosis is the formation of excess fibrous connective tissue in an organ or tissue in a reparative or reactive process. This is as opposed to formation of fibrous tissue as a normal constituent of an organ or tissue. Scarring is confluent fibrosis that obliterates the architecture of the underlying organ or tissue.

The term is also sometimes used to describe a normal healing process,[1] but this usage is less common.

Contents

Examples of fibrosis

Types

Type Most common location(s) Circumscription Cellularity Vascularity and nature of vessels Appearance of collagen Elastic fibers Picture
Nuchal fibroma Nuchal region No Very low Very low Bundles of fibers Scant
Collagenous fibroma Shoulder girdle, extremities Yes, by macroscopic appearance, but microscopically infiltrative Increased but generally low Low Scant or absent Amorphous
Fibroma of tendon sheath Distal extremities, especially the hand Yes Low to high Moderate to high, with some slitlike vessels Amorphous Absent
Scar Variable Variable Low to high Variable Amorphous Scant to absent
Elastofibroma Subscapular chest wall No Low to moderate Low Amorphous Abundant and abnormal
Desmoid-type fibromatosis Abdominal wall, shoulder girdle Yes, by macroscopic appearance, but microscopically infiltrative Moderate Moderate, mildly dilated Amorphous Absent
Keloid Upper part of back, deltoid, presternal, ear lobes No Some fibroblasts Low Amorphous thick eosinophilic bundles Scant or Absent

[2][3]

References

  1. ^ Glossary of dermatopathological terms. DermNet NZ
  2. ^ Nuchal-type fibroma. Cancer. Volume 85, Issue 1, pp. 156-163.
  3. ^ Skin Pathology. David Weedon. Second Edition.

External links

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