Fibrin glue

Fibrin glue (also called fibrin sealant) is a formulation used to create a fibrin clot.[1][2][3][4][5][6][7] It is made up of fibrinogen and thrombin[1] that are injected through one head into the site of a fibrin tear.[1] Thrombin is an enzyme and converts the fibrinogen into fibrin between 10 and 60 seconds and acts as a tissue adhesive.[6][8] It may also contain aprotinin, fibronectin and plasminogen.[9] This glue can be used for repairing dura tears, bronchial fistulas and for achieving hemostasis after spleen and liver trauma.[6] It is also employed in "no sutures" corneal transplantation. [10][11]

References

  1. ^ a b c http://www.bmj.com/cgi/content/extract/308/6934/933
  2. ^ http://www.theannals.com/cgi/content/abstract/22/12/946
  3. ^ http://www.medhelp.org/forums/gastro/archive/1054.html
  4. ^ http://content.karger.com/ProdukteDB/produkte.asp?Doi=8552
  5. ^ http://www.healthsystem.virginia.edu/internet/stac/research/spfibgl.cfm
  6. ^ a b c http://www.ijps.org/article.asp?issn=0970-0358;year=2003;volume=36;issue=1;spage=14;epage=17;aulast=Saxena
  7. ^ http://www3.interscience.wiley.com/journal/121466570/abstract
  8. ^ Spotnitz, W. . (2009). "Fibrin Sealant: Past, Present, and Future: A Brief Review". World journal of surgery 34 (4): 632–634. doi:10.1007/s00268-009-0252-7. PMID 19820991.  edit
  9. ^ Tisseel From the Swedish official drug catalog
  10. ^ Narendran N, Mohamed S, Shah S (July 2007). "No sutures corneal grafting--a novel use of overlay sutures and fibrin glue in Deep Anterior Lamellar Keratoplasty". Cont Lens Anterior Eye 30 (3): 207–9. doi:10.1016/j.clae.2007.02.007. PMID 17379570. http://linkinghub.elsevier.com/retrieve/pii/S1367-0484(07)00031-8. 
  11. ^ Dal Pizzol, MM; Roggia, MF; Kwitko, S; Marinho, DR; Rymer, S (2009). "Use of fibrin glue in ocular surgery". Arquivos brasileiros de oftalmologia 72 (3): 308–12. PMID 19668958.  edit