Fasudil

Fasudil
Systematic (IUPAC) name
5-(1,4-diazepane-1-sulfonyl)isoquinoline
Clinical data
AHFS/Drugs.com International Drug Names
Pregnancy cat.  ?
Legal status  ?
Pharmacokinetic data
Bioavailability well absorbed
Metabolism metabolized quickly to hydroxyfasudil
Half-life 0.76 hours. Active metabolite (hydroxyfasudil) 4.66 hours.
Identifiers
CAS number 103745-39-7
ATC code C04AX32
PubChem CID 3547
UNII Q0CH43PGXS Y
KEGG D07941 Y
ChEMBL CHEMBL38380 Y
Chemical data
Formula C14H17N3O2S 
Mol. mass 291.36 g/mol
SMILES eMolecules & PubChem
 Y(what is this?)  (verify)

Fasudil Hydrochloride (INN) is a potent Rho-kinase inhibitor and vasodilator.[1] Since it was discovered, it has been used for the treatment of cerebral vasospasm, which is often due to subarachnoid hemorrhage,[2] as well as to improve the cognitive decline seen in stroke victims. It has been found to be effective for the treatment of pulmonary hypertension.[3] It was demonstrated in February 2009 that Fasudil could also be used to enhance memory and improve the prognosis of Alzheimers patients.[4]

References

  1. ^ . Science Daily. http://www.sciencedaily.com/releases/2009/02/090202102932.htm 
  2. ^ Shibuya M, Suzuki Y (September 1993). "[Treatment of cerebral vasospasm by a protein kinase inhibitor AT 877]" (in Japanese). No to Shinkei 45 (9): 819–24. PMID 8217408. 
  3. ^ Doggrell SA (2005). "Rho-kinase inhibitors show promise in pulmonary hypertension.". Expert Opin Investig Drugs 14 (9): 1157–1159. doi:10.1517/13543784.14.9.1157. PMID 16144499. 
  4. ^ Huentelman, Matthew J.; Stephan, DA; Talboom, J; Corneveaux, JJ; Reiman, DM; Gerber, JD; Barnes, CA; Alexander, GE et al. (2009). "Peripheral delivery of a ROCK inhibitor improves learning and working memory". Behavioral Neuroscience 123 (1): 218. doi:10.1037/a0014260. PMC 2701389. PMID 19170447. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2701389 
Peripheral vasodilators (C04)
2-amino-1-phenylethanol derivatives
Imidazoline derivatives/
Alpha blockers
Niacin and derivatives
Purine derivatives
Ergot alkaloids
Other peripheral vasodilators

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