Familial aortic dissection

Familial aortic dissection is an autosomal dominant inherited disease that will result in dissection of the aorta, and dissecting aneurysm of the aorta, or rarely aortic or arterial dilation at a young age, yet the basic defect remains unknown.[1] it can occur in the absence of clinical features of Marfan syndrome and of systemic hypertension.[2][3][4][5][6]

External links

References

  1. ^ Nicod P, Bloor C, Godfrey M, et al. (March 1989). "Familial aortic dissecting aneurysm". J. Am. Coll. Cardiol. 13 (4): 811–9. doi:10.1016/0735-1097(89)90221-0. PMID 2647812. 
  2. ^ Disertori M, Bertagnolli C, Thiene G, et al. (August 1991). "[Familial dissecting aortic aneurysm]" (in Italian). G Ital Cardiol 21 (8): 849–53. PMID 1769452. 
  3. ^ Cucchi G (February 1997). "[Familial aortic dissection in a young woman. A clinical case and review of the literature]" (in Italian). Cardiologia 42 (2): 211–3. PMID 9138854. 
  4. ^ Marwick TH, Woodhouse SP, Birchley IN, Strong RW (November 1987). "Management of familial aortic dissection". Chest 92 (5): 954–6. doi:10.1378/chest.92.5.954. PMID 3665621. http://www.chestjournal.org/cgi/pmidlookup?view=long&pmid=3665621. 
  5. ^ Milewicz DM, Guo DC, Tran-Fadulu V, et al. (2008). "Genetic basis of thoracic aortic aneurysms and dissections: focus on smooth muscle cell contractile dysfunction". Annu Rev Genomics Hum Genet 9: 283–302. doi:10.1146/annurev.genom.8.080706.092303. PMID 18544034. 
  6. ^ Guo DC, Pannu H, Tran-Fadulu V, et al. (December 2007). "Mutations in smooth muscle alpha-actin (ACTA2) lead to thoracic aortic aneurysms and dissections". Nat. Genet. 39 (12): 1488–93. doi:10.1038/ng.2007.6. PMID 17994018.