FZR1

Fizzy/cell division cycle 20 related 1 (Drosophila)
Identifiers
Symbols FZR1; CDC20C; CDH1; FZR; FZR2; HCDH; HCDH1; KIAA1242
External IDs OMIM603619 MGI1926790 HomoloGene9444 GeneCards: FZR1 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 51343 56371
Ensembl ENSG00000105325 ENSMUSG00000020235
UniProt Q9UM11 Q3TQ38
RefSeq (mRNA) NM_001136197.1 NM_019757.1
RefSeq (protein) NP_001129669.1 NP_062731.1
Location (UCSC) Chr 19:
3.51 – 3.54 Mb
Chr 10:
80.83 – 80.84 Mb
PubMed search [1] [2]

Fizzy-related protein homolog is a protein that in humans is encoded by the FZR1 gene.[1][2][3]

Interactions

FZR1 has been shown to interact with CDC27[4][5] and FBXO5.[6]

References

  1. ^ Fang G, Yu H, Kirschner MW (Sep 1998). "Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1". Mol Cell 2 (2): 163–171. doi:10.1016/S1097-2765(00)80126-4. PMID 9734353. 
  2. ^ Sorensen CS, Lukas C, Kramer ER, Peters JM, Bartek J, Lukas J (Oct 2000). "Nonperiodic activity of the human anaphase-promoting complex-Cdh1 ubiquitin ligase results in continuous DNA synthesis uncoupled from mitosis". Mol Cell Biol 20 (20): 7613–7623. doi:10.1128/MCB.20.20.7613-7623.2000. PMC 86321. PMID 11003657. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=86321. 
  3. ^ "Entrez Gene: FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51343. 
  4. ^ Zhou, Yuan; Ching Yick-Pang, Ng Raymond W M, Jin Dong-Yan (Sep. 2003). "Differential expression, localization and activity of two alternatively spliced isoforms of human APC regulator CDH1". Biochem. J. (England) 374 (Pt 2): 349–58. doi:10.1042/BJ20030600. PMC 1223613. PMID 12797865. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1223613. 
  5. ^ Kramer, E R; Gieffers C, Hölzl G, Hengstschläger M, Peters J M (Nov. 1998). "Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family". Curr. Biol. (ENGLAND) 8 (22): 1207–S4. doi:10.1016/S0960-9822(07)00510-6. ISSN 0960-9822. PMID 9811605. 
  6. ^ Hsu, Jerry Y; Reimann Julie D R, Sørensen Claus S, Lukas Jiri, Jackson Peter K (May. 2002). "E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)". Nat. Cell Biol. (England) 4 (5): 358–366. doi:10.1038/ncb785. ISSN 1465-7392. PMID 11988738. 

Further reading