FRS2

Fibroblast growth factor receptor substrate 2

PDB rendering based on 1xr0.
Identifiers
Symbols FRS2; FRS2A; FRS2alpha; SNT; SNT-1; SNT1
External IDs OMIM: 607743 MGI: 1100860 HomoloGene: 4846 GeneCards: FRS2 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 10818 327826
Ensembl ENSG00000166225 ENSMUSG00000020170
UniProt Q8WU20 Q8C180
RefSeq (mRNA) NM_001042555.1 NM_177798.3
RefSeq (protein) NP_001036020.1 NP_808466.1
Location (UCSC) Chr 12:
69.86 – 69.97 Mb		 Chr 10:
116.51 – 116.59 Mb
PubMed search [1] [2]

Fibroblast growth factor receptor substrate 2 is a protein that in humans is encoded by the FRS2 gene.[1][2][3]

Interactions

FRS2 has been shown to interact with PRKCI,[4] Grb2,[5][6][7][8] PTPN11,[9][10][11] Fibroblast growth factor receptor 1,[2][12][13][14] TrkA,[7] Cbl gene[6] and SOS1.[6][8][15]

References

  1. ^ Wang JK, Xu H, Li HC, Goldfarb M (October 1996). "Broadly expressed SNT-like proteins link FGF receptor stimulation to activators of Ras". Oncogene 13 (4): 721–9. PMID 8761293. 
  2. ^ a b Xu H, Lee KW, Goldfarb M (August 1998). "Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins". J Biol Chem 273 (29): 17987–90. doi:10.1074/jbc.273.29.17987. PMID 9660748. 
  3. ^ "Entrez Gene: FRS2 Fibroblast growth factor receptor substrate 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10818. 
  4. ^ Lim, Y P; Low B C, Lim J, Wong E S, Guy G R (July 1999). "Association of atypical protein kinase C isotypes with the docker protein FRS2 in fibroblast growth factor signaling". J. Biol. Chem. (UNITED STATES) 274 (27): 19025–34. doi:10.1074/jbc.274.27.19025. ISSN 0021-9258. PMID 10383403. 
  5. ^ Ong, S H; Goh K C, Lim Y P, Low B C, Klint P, Claesson-Welsh L, Cao X, Tan Y H, Guy G R (August 1996). "Suc1-associated neurotrophic factor target (SNT) protein is a major FGF-stimulated tyrosine phosphorylated 90-kDa protein which binds to the SH2 domain of GRB2". Biochem. Biophys. Res. Commun. (UNITED STATES) 225 (3): 1021–6. doi:10.1006/bbrc.1996.1288. ISSN 0006-291X. PMID 8780727. 
  6. ^ a b c Wong, Andy; Lamothe Betty, Lee Arnold, Schlessinger Joseph, Lax Irit, Li Arnold (May 2002). "FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl". Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (10): 6684–9. doi:10.1073/pnas.052138899. ISSN 0027-8424. PMC 124463. PMID 11997436. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=124463. 
  7. ^ a b Meakin, S O; MacDonald J I, Gryz E A, Kubu C J, Verdi J M (April 1999). "The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation". J. Biol. Chem. (UNITED STATES) 274 (14): 9861–70. doi:10.1074/jbc.274.14.9861. ISSN 0021-9258. PMID 10092678. 
  8. ^ a b Kouhara, H; Hadari Y R, Spivak-Kroizman T, Schilling J, Bar-Sagi D, Lax I, Schlessinger J (May 1997). "A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway". Cell (UNITED STATES) 89 (5): 693–702. doi:10.1016/S0092-8674(00)80252-4. ISSN 0092-8674. PMID 9182757. 
  9. ^ Delahaye, L; Rocchi S, Van Obberghen E (February 2000). "Potential involvement of FRS2 in insulin signaling". Endocrinology (UNITED STATES) 141 (2): 621–8. doi:10.1210/en.141.2.621. ISSN 0013-7227. PMID 10650943. 
  10. ^ Kurokawa, K; Iwashita T, Murakami H, Hayashi H, Kawai K, Takahashi M (April 2001). "Identification of SNT/FRS2 docking site on RET receptor tyrosine kinase and its role for signal transduction". Oncogene (England) 20 (16): 1929–38. doi:10.1038/sj.onc.1204290. ISSN 0950-9232. PMID 11360177. 
  11. ^ Hadari, Y R; Kouhara H, Lax I, Schlessinger J (July 1998). "Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation". Mol. Cell. Biol. (UNITED STATES) 18 (7): 3966–73. ISSN 0270-7306. PMC 108981. PMID 9632781. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=108981. 
  12. ^ Yan, Kelley S; Kuti Miklos, Yan Sherry, Mujtaba Shiraz, Farooq Amjad, Goldfarb Mitchell P, Zhou Ming-Ming (May 2002). "FRS2 PTB domain conformation regulates interactions with divergent neurotrophic receptors". J. Biol. Chem. (United States) 277 (19): 17088–94. doi:10.1074/jbc.M107963200. ISSN 0021-9258. PMID 11877385. 
  13. ^ Ong, S H; Guy G R, Hadari Y R, Laks S, Gotoh N, Schlessinger J, Lax I (February 2000). "FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors". Mol. Cell. Biol. (UNITED STATES) 20 (3): 979–89. doi:10.1128/MCB.20.3.979-989.2000. ISSN 0270-7306. PMC 85215. PMID 10629055. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=85215. 
  14. ^ Dhalluin, C; Yan K S, Plotnikova O, Lee K W, Zeng L, Kuti M, Mujtaba S, Goldfarb M P, Zhou M M (October 2000). "Structural basis of SNT PTB domain interactions with distinct neurotrophic receptors". Mol. Cell (United States) 6 (4): 921–9. doi:10.1016/S1097-2765(05)00087-0. ISSN 1097-2765. PMID 11090629. 
  15. ^ Foehr, E D; Tatavos A, Tanabe E, Raffioni S, Goetz S, Dimarco E, De Luca M, Bradshaw R A (May 2000). "Discoidin domain receptor 1 (DDR1) signaling in PC12 cells: activation of juxtamembrane domains in PDGFR/DDR/TrkA chimeric receptors". FASEB J. (UNITED STATES) 14 (7): 973–81. ISSN 0892-6638. PMID 10783152. 

Further reading