FLT3LG

Fms-related tyrosine kinase 3 ligand

PDB rendering based on 1ete.
Identifiers
Symbols FLT3LG; FL; FLT3L
External IDs OMIM: 600007 MGI: 95560 HomoloGene: 48021 GeneCards: FLT3LG Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 2323 14256
Ensembl ENSG00000090554 ENSMUSG00000089989
UniProt P49771 Q61104
RefSeq (mRNA) NM_001204502.1 NM_013520.3
RefSeq (protein) NP_001191431.1 NP_038548.3
Location (UCSC) Chr 19:
49.98 – 49.99 Mb		 Chr 7:
52.39 – 52.39 Mb
PubMed search [1] [2]

Fms-related tyrosine kinase 3 ligand (FLT3LG) is a protein which in humans is encoded by the FLT3LG gene.[1][2][3]

Flt3 ligand (FL) is a hematopoietic four helical bundle cytokine. It is structurally homologous to stem cell factor (SCF) and colony stimulating facor 1 (CSF-1). In synergy with other growth factors, Flt3 ligand stimulates the proliferation and differentiation of various blood cell progenitors.

References

  1. ^ "Entrez Gene: FLT3LG fms-related tyrosine kinase 3 ligand". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2323. 
  2. ^ Hannum C, Culpepper J, Campbell D, McClanahan T, Zurawski S, Bazan JF, Kastelein R, Hudak S, Wagner J, Mattson J (April 1994). "Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs". Nature 368 (6472): 643–8. doi:10.1038/368643a0. PMID 8145851. 
  3. ^ Lyman SD, James L, Escobar S, Downey H, de Vries P, Brasel K, Stocking K, Beckmann MP, Copeland NG, Cleveland LS (January 1995). "Identification of soluble and membrane-bound isoforms of the murine flt3 ligand generated by alternative splicing of mRNAs". Oncogene 10 (1): 149–57. PMID 7824267. 

Further reading

  • Lyman SD, James L, Vanden Bos T et al. (1994). "Molecular cloning of a ligand for the flt3/flk-2 tyrosine kinase receptor: a proliferative factor for primitive hematopoietic cells". Cell 75 (6): 1157–67. doi:10.1016/0092-8674(93)90325-K. PMID 7505204. 
  • Lyman SD, Stocking K, Davison B et al. (1995). "Structural analysis of human and murine flt3 ligand genomic loci". Oncogene 11 (6): 1165–72. PMID 7566977. 
  • Lyman SD, James L, Escobar S et al. (1995). "Identification of soluble and membrane-bound isoforms of the murine flt3 ligand generated by alternative splicing of mRNAs". Oncogene 10 (1): 149–57. PMID 7824267. 
  • Hannum C, Culpepper J, Campbell D et al. (1994). "Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs". Nature 368 (6472): 643–8. doi:10.1038/368643a0. PMID 8145851. 
  • Lyman SD, James L, Johnson L et al. (1994). "Cloning of the human homologue of the murine flt3 ligand: a growth factor for early hematopoietic progenitor cells". Blood 83 (10): 2795–801. PMID 8180375. 
  • Slanicka Krieger M, Nissen C, Manz CY et al. (1998). "The membrane-bound isoform of stem cell factor synergizes with soluble flt3 ligand in supporting early hematopoietic cells in long-term cultures of normal and aplastic anemia bone marrow". Exp. Hematol. 26 (5): 365–73. PMID 9590652. 
  • Graddis TJ, Brasel K, Friend D et al. (1998). "Structure-function analysis of FLT3 ligand-FLT3 receptor interactions using a rapid functional screen". J. Biol. Chem. 273 (28): 17626–33. doi:10.1074/jbc.273.28.17626. PMID 9651358. 
  • Solanilla A, Grosset C, Lemercier C et al. (2000). "Expression of Flt3-ligand by the endothelial cell". Leukemia 14 (1): 153–62. doi:10.1038/sj.leu.2401635. PMID 10637491. 
  • Savvides SN, Boone T, Karplus P.A. (2000). "Flt3 ligand structure and unexpected commonalities of helical bundles and cystine knots". Nat. Struct. Biol. 7 (6): 486–91. doi:10.1038/75896. PMID 10881197. 
  • Chklovskaia E, Nissen C, Landmann L et al. (2001). "Cell-surface trafficking and release of flt3 ligand from T lymphocytes is induced by common cytokine receptor gamma-chain signaling and inhibited by cyclosporin A". Blood 97 (4): 1027–34. doi:10.1182/blood.V97.4.1027. PMID 11159533. 
  • Agrawal DK, Hopfenspirger MT, Chavez J, Talmadge JE (2002). "Flt3 ligand: a novel cytokine prevents allergic asthma in a mouse model". Int. Immunopharmacol. 1 (12): 2081–9. doi:10.1016/S1567-5769(01)00122-9. PMID 11710537. 
  • Li H, Cai Y, Xu J (2002). "[Localization of a FLT3 ligand isoform in human tissues]". Zhonghua Xue Ye Xue Za Zhi 20 (6): 285–7. PMID 11721383. 
  • Feugier P, Jo DY, Shieh JH et al. (2003). "Ex vivo expansion of stem and progenitor cells in co-culture of mobilized peripheral blood CD34+ cells on human endothelium transfected with adenovectors expressing thrombopoietin, c-kit ligand, and Flt-3 ligand". J. Hematother. Stem Cell Res. 11 (1): 127–38. doi:10.1089/152581602753448595. PMID 11847009. 
  • O'Keeffe M, Hochrein H, Vremec D et al. (2002). "Effects of administration of progenipoietin 1, Flt-3 ligand, granulocyte colony-stimulating factor, and pegylated granulocyte-macrophage colony-stimulating factor on dendritic cell subsets in mice". Blood 99 (6): 2122–30. doi:10.1182/blood.V99.6.2122. PMID 11877288. 
  • Retzlaff S, Padró T, Koch P et al. (2002). "Interleukin 8 and Flt3 ligand as markers of advanced disease in primary gastrointestinal non-Hodgkin's lymphoma". Oncol. Rep. 9 (3): 525–7. PMID 11956621. 
  • Sigurjónsson OE, Gudmundsson KO, Haraldsdóttir V et al. (2003). "Flt3/Flk-2-ligand in synergy with thrombopoietin delays megakaryocyte development and increases the numbers of megakaryocyte progenitor cells in serum-free cultures initiated with CD34+ cells". J. Hematother. Stem Cell Res. 11 (2): 389–400. doi:10.1089/152581602753658574. PMID 11983110. 
  • Vávrová J, Vokurková D, Mareková M et al. (2002). "Antiapoptotic cytokine IL-3 + SCF + FLT3L influence on proliferation of gamma-irradiated AC133+/CD34+ progenitor cells". Folia Biol. (Praha) 48 (2): 51–7. PMID 12002675. 
  • Testa U, Torelli GF, Riccioni R et al. (2002). "Human acute stem cell leukemia with multilineage differentiation potential via cascade activation of growth factor receptors". Blood 99 (12): 4634–7. doi:10.1182/blood.V99.12.4634. PMID 12036900. 
  • Mosca PJ, Hobeika AC, Colling K et al. (2002). "Multiple signals are required for maturation of human dendritic cells mobilized in vivo with Flt3 ligand". J. Leukoc. Biol. 72 (3): 546–53. PMID 12223523. 
  • Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.