FLOT1

Flotillin 1

Identifiers

External IDs

OMIM: 606998 MGI: 1100500 HomoloGene: 31337 GeneCards: FLOT1 Gene

Gene Ontology
Molecular function	• protein binding • ionotropic glutamate receptor binding
Cellular component	• membrane fraction • endosome • microtubule organizing center • plasma membrane • caveola • signalosome • integral to membrane • flotillin complex • centriolar satellite • melanosome • membrane raft
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 6:
30.8 – 30.82 Mb

Chr 17:
35.96 – 35.97 Mb

PubMed search

[1]

[2]

Flotillin-1 is a protein that in humans is encoded by the FLOT1 gene.^[1]

Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. FLOT1 encodes a caveolae-associated, integral membrane protein. The function of flotillin 1 has not been determined.^[1]

Interactions

FLOT1 has been shown to interact with SORBS1.^[2]^[3]^[4]

References

^ ^a ^b "Entrez Gene: FLOT1 flotillin 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10211.
^ Haglund, Kaisa; Ivankovic-Dikic Inga, Shimokawa Noriaki, Kruh Gary D, Dikic Ivan (May. 2004). "Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites". J. Cell. Sci. (England) 117 (Pt 12): 2557–68. doi:10.1242/jcs.01148. ISSN 0021-9533. PMID 15128873.
^ Baumann, C A; Ribon V, Kanzaki M, Thurmond D C, Mora S, Shigematsu S, Bickel P E, Pessin J E, Saltiel A R (Sep. 2000). "CAP defines a second signalling pathway required for insulin-stimulated glucose transport". Nature (ENGLAND) 407 (6801): 202–7. doi:10.1038/35025089. ISSN 0028-0836. PMID 11001060.
^ Kimura, A; Baumann C A, Chiang S H, Saltiel A R (Jul. 2001). "The sorbin homology domain: a motif for the targeting of proteins to lipid rafts". Proc. Natl. Acad. Sci. U.S.A. (United States) 98 (16): 9098–103. doi:10.1073/pnas.151252898. ISSN 0027-8424. PMC 55379. PMID 11481476. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=55379.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Bickel PE, Scherer PE, Schnitzer JE, et al. (1997). "Flotillin and epidermal surface antigen define a new family of caveolae-associated integral membrane proteins.". J. Biol. Chem. 272 (21): 13793–802. doi:10.1074/jbc.272.21.13793. PMID 9153235.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Volonte D, Galbiati F, Li S, et al. (1999). "Flotillins/cavatellins are differentially expressed in cells and tissues and form a hetero-oligomeric complex with caveolins in vivo. Characterization and epitope-mapping of a novel flotillin-1 monoclonal antibody probe.". J. Biol. Chem. 274 (18): 12702–9. doi:10.1074/jbc.274.18.12702. PMID 10212252.
Hazarika P, Dham N, Patel P, et al. (1999). "Flotillin 2 is distinct from epidermal surface antigen (ESA) and is associated with filopodia formation.". J. Cell. Biochem. 75 (1): 147–59. doi:10.1002/(SICI)1097-4644(19991001)75:1<147::AID-JCB15>3.0.CO;2-D. PMID 10462713.
Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=16901.
Baumann CA, Ribon V, Kanzaki M, et al. (2000). "CAP defines a second signalling pathway required for insulin-stimulated glucose transport.". Nature 407 (6801): 202–7. doi:10.1038/35025089. PMID 11001060.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310934.
Salzer U, Prohaska R (2001). "Stomatin, flotillin-1, and flotillin-2 are major integral proteins of erythrocyte lipid rafts.". Blood 97 (4): 1141–3. doi:10.1182/blood.V97.4.1141. PMID 11159550.
Edgar AJ, Polak JM (2001). "Flotillin-1: gene structure: cDNA cloning from human lung and the identification of alternative polyadenylation signals.". Int. J. Biochem. Cell Biol. 33 (1): 53–64. doi:10.1016/S1357-2725(00)00069-8. PMID 11167132.
Kimura A, Baumann CA, Chiang SH, Saltiel AR (2001). "The sorbin homology domain: a motif for the targeting of proteins to lipid rafts.". Proc. Natl. Acad. Sci. U.S.A. 98 (16): 9098–103. doi:10.1073/pnas.151252898. PMC 55379. PMID 11481476. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=55379.
Stuermer CA, Lang DM, Kirsch F, et al. (2002). "Glycosylphosphatidyl inositol-anchored proteins and fyn kinase assemble in noncaveolar plasma membrane microdomains defined by reggie-1 and -2.". Mol. Biol. Cell 12 (10): 3031–45. PMC 60153. PMID 11598189. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=60153.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Girardot N, Allinquant B, Duyckaerts C (2004). "[Lipid rafts, flotillin-1 and Alzheimer disease]". J. Soc. Biol. 197 (3): 223–9. PMID 14708344.
Wakasugi K, Nakano T, Kitatsuji C, Morishima I (2004). "Human neuroglobin interacts with flotillin-1, a lipid raft microdomain-associated protein.". Biochem. Biophys. Res. Commun. 318 (2): 453–60. doi:10.1016/j.bbrc.2004.04.045. PMID 15120622.
Haglund K, Ivankovic-Dikic I, Shimokawa N, et al. (2004). "Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites.". J. Cell. Sci. 117 (Pt 12): 2557–68. doi:10.1242/jcs.01148. PMID 15128873.
Bared SM, Buechler C, Boettcher A, et al. (2005). "Association of ABCA1 with syntaxin 13 and flotillin-1 and enhanced phagocytosis in tangier cells.". Mol. Biol. Cell 15 (12): 5399–407. doi:10.1091/mbc.E04-03-0182. PMC 532019. PMID 15469992. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=532019.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Jacobowitz DM, Kallarakal AT (2005). "Flotillin-1 in the substantia nigra of the Parkinson brain and a predominant localization in catecholaminergic nerves in the rat brain.". Neurotoxicity research 6 (4): 245–57. doi:10.1007/BF03033435. PMID 15545008.
Pope SN, Lee IR (2005). "Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin.". J. Steroid Biochem. Mol. Biol. 94 (1-3): 203–8. doi:10.1016/j.jsbmb.2005.01.007. PMID 15862967.

FLOT1

Interactions

References

Further reading