FK506 binding protein like | |||||||||||||
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Identifiers | |||||||||||||
Symbols | FKBPL; DIR1; NG7; WISP39 | ||||||||||||
External IDs | MGI: 1932127 HomoloGene: 10529 GeneCards: FKBPL Gene | ||||||||||||
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Orthologs | |||||||||||||
Species | Human | Mouse | |||||||||||
Entrez | 63943 | 56299 | |||||||||||
Ensembl | ENSG00000204315 | ENSMUSG00000033739 | |||||||||||
UniProt | Q9UIM3 | O35450 | |||||||||||
RefSeq (mRNA) | NM_022110 | NM_019873.2 | |||||||||||
RefSeq (protein) | NP_071393 | NP_063926.1 | |||||||||||
Location (UCSC) | Chr 6: 32.2 – 32.21 Mb |
Chr 17: 34.78 – 34.78 Mb |
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PubMed search | [1] | [2] |
FK506-binding protein like, also known as FKBPL is a protein that in humans is encoded by the FKBPL gene.[1]
FKBPL has similarity to the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The encoded protein is thought to have a potential role in the induced radioresistance. Also it appears to have some involvement in the control of the cell cycle.[2]
FKBPL is involved in cellular response to stress. It was first isolated in 1999 and was initially named DIR1.[3] It was later reclassified because of its homology to the FKBP family of proteins and was renamed FKBP-like (FKBPL). A separate study that found it to be involved in the stabilisation of newly synthesised p21 termed it Wisp39.[4]
It is known to interact with Hsp90, glucocorticoid receptor and dynamitin and may play a role in signalling, like other FKBPs.[5]
FKBPL has also been shown to influence estrogen receptor signalling and can have a determinant effect on response to the breast cancer drug tamoxifen.[6]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.