FKBP2
FK506-binding protein 2 is a protein that in humans is encoded by the FKBP2 gene.[1][2]
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is thought to function as an ER chaperone and may also act as a component of membrane cytoskeletal scaffolds. This gene has two alternatively spliced transcript variants that encode the same isoform. Multiple polyadenylation sites have been described for this gene, but the full length nature of this gene has not been determined.[2]
Interactions
FKBP2 has been shown to interact with ARFGEF1[3] and EPB41L2.[4]
References
- ^ Jin YJ, Albers MW, Lane WS, Bierer BE, Schreiber SL, Burakoff SJ (Sep 1991). "Molecular cloning of a membrane-associated human FK506- and rapamycin-binding protein, FKBP-13". Proc Natl Acad Sci U S A 88 (15): 6677–81. doi:10.1073/pnas.88.15.6677. PMC 52151. PMID 1713687. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=52151.
- ^ a b "Entrez Gene: FKBP2 FK506 binding protein 2, 13kDa". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2286.
- ^ Padilla, Philip Ian; Chang Min-Ju, Pacheco-Rodriguez Gustavo, Adamik Ronald, Moss Joel, Vaughan Martha (Mar. 2003). "Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): Effects of FK506". Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (5): 2322–7. doi:10.1073/pnas.2628047100. ISSN 0027-8424. PMC 151339. PMID 12606707. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=151339.
- ^ Walensky, L D; Gascard P, Fields M E, Blackshaw S, Conboy J G, Mohandas N, Snyder S H (Apr. 1998). "The 13-kD FK506 Binding Protein, FKBP13, Interacts with a Novel Homologue of the Erythrocyte Membrane Cytoskeletal Protein 4.1". J. Cell Biol. (UNITED STATES) 141 (1): 143–53. doi:10.1083/jcb.141.1.143. ISSN 0021-9525. PMC 2132710. PMID 9531554. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2132710.
Further reading
- DiLella AG, Hawkins A, Craig RJ et al. (1993). "Chromosomal band assignments of the genes encoding human FKBP12 and FKBP13". Biochem. Biophys. Res. Commun. 189 (2): 819–23. doi:10.1016/0006-291X(92)92276-4. PMID 1281998.
- Hendrickson BA, Zhang W, Craig RJ et al. (1994). "Structural organization of the genes encoding human and murine FK506-binding protein (FKBP) 13 and comparison to FKBP1". Gene 134 (2): 271–5. doi:10.1016/0378-1119(93)90106-D. PMID 7505249.
- Bush KT, Hendrickson BA, Nigam SK (1994). "Induction of the FK506-binding protein, FKBP13, under conditions which misfold proteins in the endoplasmic reticulum". Biochem. J. 303 ( Pt 3) (Pt 3): 705–8. PMC 1137603. PMID 7526846. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1137603.
- Nigam SK, Jin YJ, Jin MJ et al. (1993). "Localization of the FK506-binding protein, FKBP 13, to the lumen of the endoplasmic reticulum". Biochem. J. 294 ( Pt 2) (Pt 2): 511–5. PMC 1134484. PMID 8373365. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1134484.
- Walensky LD, Gascard P, Fields ME et al. (1998). "The 13-kD FK506 Binding Protein, FKBP13, Interacts with a Novel Homologue of the Erythrocyte Membrane Cytoskeletal Protein 4.1". J. Cell Biol. 141 (1): 143–53. doi:10.1083/jcb.141.1.143. PMC 2132710. PMID 9531554. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2132710.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Padilla PI, Chang MJ, Pacheco-Rodriguez G et al. (2003). "Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): Effects of FK506". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2322–7. doi:10.1073/pnas.2628047100. PMC 151339. PMID 12606707. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=151339.
- Willingham S, Outeiro TF, DeVit MJ et al. (2003). "Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein". Science 302 (5651): 1769–72. doi:10.1126/science.1090389. PMID 14657499.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Won J, Kim M, Yi YW et al. (2005). "A magnetic nanoprobe technology for detecting molecular interactions in live cells". Science 309 (5731): 121–5. doi:10.1126/science.1112869. PMID 15994554.
- Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Lim J, Hao T, Shaw C et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
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2pbc: FK506-binding protein 2
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