FKBP10

FK506 binding protein 10, 65 kDa

Identifiers

FKBP10; FKBP65; FLJ20683; FLJ22041; FLJ23833; OI6; PPIASE; hFKBP65

External IDs

OMIM: 607063 MGI: 104769 HomoloGene: 7718 GeneCards: FKBP10 Gene

5.2.1.8

Gene Ontology
Molecular function	• peptidyl-prolyl cis-trans isomerase activity • calcium ion binding • FK506 binding • isomerase activity
Cellular component	• endoplasmic reticulum • endoplasmic reticulum lumen • membrane
Biological process	• protein peptidyl-prolyl isomerization • protein folding • peptidyl-proline modification
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 17:
39.97 – 39.98 Mb

Chr 11:
100.28 – 100.29 Mb

PubMed search

[1]

[2]

FK506-binding protein 10 is a protein that in humans is encoded by the FKBP10 gene.^[1]^[2]^[3]

The protein encoded by this gene belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase family. It is located in endoplasmic reticulum and acts as molecular chaperones. Two alternatively spliced variants, which encode different isoform, are reported.^[3]

References

^ Patterson CE, Schaub T, Coleman EJ, Davis EC (Feb 2001). "Developmental Regulation of FKBP65: An ER-localized Extracellular Matrix Binding-Protein". Mol Biol Cell 11 (11): 3925–35. PMC 15047. PMID 11071917. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=15047.
^ Ishikawa Y, Vranka J, Wirz J, Nagata K, Bachinger HP (Nov 2008). "The rough endoplasmic reticulum-resident FK506-binding protein FKBP65 is a molecular chaperone that interacts with collagens". J Biol Chem 283 (46): 31584–90. doi:10.1074/jbc.M802535200. PMID 18786928.
^ ^a ^b "Entrez Gene: FKBP10 FK506 binding protein 10, 65 kDa". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=60681.

Patterson CE, Gao J, Rooney AP, Davis EC (2002). "Genomic organization of mouse and human 65 kDa FK506-binding protein genes and evolution of the FKBP multigene family". Genomics 79 (6): 881–9. doi:10.1006/geno.2002.6777. PMID 12036304.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Zhang H, Li XJ, Martin DB, Aebersold R (2003). "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry". Nat. Biotechnol. 21 (6): 660–6. doi:10.1038/nbt827. PMID 12754519.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Won J, Kim M, Yi YW et al. (2005). "A magnetic nanoprobe technology for detecting molecular interactions in live cells". Science 309 (5731): 121–5. doi:10.1126/science.1112869. PMID 15994554.
Otsuki T, Ota T, Nishikawa T et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Foster LJ, Rudich A, Talior I et al. (2006). "Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC)". J. Proteome Res. 5 (1): 64–75. doi:10.1021/pr0502626. PMID 16396496.

Isomerases: geometric (EC 5.2)

5.2.1	FKBP: FKBP1A · FKBP1B · FKBP2 · FKBP3 · FKBP5 · FKBP6 · FKBP8 · FKBP9 · FKBP10 · FKBP52 · FKBPL other: Cyclophilin · Parvulin · Prolyl isomerase

B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6

FKBP10

References

Further reading