FEZ1

Fasciculation and elongation protein zeta 1 (zygin I)
Identifiers
Symbols FEZ1;
External IDs OMIM604825 MGI2670976 HomoloGene21063 GeneCards: FEZ1 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 9638 235180
Ensembl ENSG00000149557 ENSMUSG00000032118
UniProt Q99689 Q3UU92
RefSeq (mRNA) NM_005103.4 NM_183171.4
RefSeq (protein) NP_005094.1 NP_898994.2
Location (UCSC) Chr 11:
125.32 – 125.37 Mb
Chr 9:
36.63 – 36.69 Mb
PubMed search [1] [2]

Fasciculation and elongation protein zeta-1 is a protein that in humans is encoded by the FEZ1 gene.[1][2][3]

This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Expression of this gene in C. elegans unc-76 mutants can restore to the mutants partial locomotion and axonal fasciculation, suggesting that it also functions in axonal outgrowth. The N-terminal half of the gene product is highly acidic. Alternatively spliced transcript variants encoding different isoforms of this protein have been described.[3]

This protein is present in neurons, and it is believed to block the process of infection of these cells by HIV.[4]

Interactions

FEZ1 has been shown to interact with Protein kinase Mζ,[5] NBR1[6] and DISC1.[7]

References

  1. ^ Bloom L, Horvitz HR (May 1997). "The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation". Proc Natl Acad Sci U S A 94 (7): 3414–9. doi:10.1073/pnas.94.7.3414. PMC 20384. PMID 9096408. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=20384. 
  2. ^ Suzuki T, Okada Y, Semba S, Orba Y, Yamanouchi S, Endo S, Tanaka S, Fujita T, Kuroda S, Nagashima K, Sawa H (Jun 2005). "Identification of FEZ1 as a protein that interacts with JC virus agnoprotein and microtubules: role of agnoprotein-induced dissociation of FEZ1 from microtubules in viral propagation". J Biol Chem 280 (26): 24948–56. doi:10.1074/jbc.M411499200. PMID 15843383. 
  3. ^ a b "Entrez Gene: FEZ1 fasciculation and elongation protein zeta 1 (zygin I)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9638. 
  4. ^ Haedicke, J.; Brown, C.; Naghavi, H. (Aug 2009). "The brain-specific factor FEZ1 is a determinant of neuronal susceptibility to HIV-1 infection". Proceedings of the National Academy of Sciences 106 (33): 14040–14045. Bibcode 2009PNAS..10614040H. doi:10.1073/pnas.0900502106. ISSN 0027-8424. PMC 2729016. PMID 19667186. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2729016.  edit
  5. ^ Kuroda, S; Nakagawa N, Tokunaga C, Tatematsu K, Tanizawa K (Feb. 1999). "Mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth is a protein kinase C zeta-interacting protein". J. Cell Biol. (UNITED STATES) 144 (3): 403–11. doi:10.1083/jcb.144.3.403. ISSN 0021-9525. PMC 2132904. PMID 9971736. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2132904. 
  6. ^ Whitehouse, Caroline; Chambers Julie, Howe Kathy, Cobourne Martyn, Sharpe Paul, Solomon Ellen (Jan. 2002). "NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube". Eur. J. Biochem. (Germany) 269 (2): 538–45. doi:10.1046/j.0014-2956.2001.02681.x. ISSN 0014-2956. PMID 11856312. 
  7. ^ Miyoshi, K; Honda A, Baba K, Taniguchi M, Oono K, Fujita T, Kuroda S, Katayama T, Tohyama M (Jul. 2003). "Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth". Mol. Psychiatry (England) 8 (7): 685–94. doi:10.1038/sj.mp.4001352. ISSN 1359-4184. PMID 12874605. 

Further reading