FCRL2

Fc receptor-like 2

Identifiers

FCRL2; FCRH2; IFGP4; IRTA4; SPAP1; SPAP1A; SPAP1B; SPAP1C

External IDs

OMIM: 606509 HomoloGene: 57121 GeneCards: FCRL2 Gene

Gene Ontology
Molecular function	• receptor activity • SH3/SH2 adaptor activity
Cellular component	• soluble fraction • plasma membrane • integral to membrane
Biological process	• cell-cell signaling
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

n/a

n/a

n/a

RefSeq (mRNA)

NM_030764

n/a

RefSeq (protein)

NP_110391

n/a

Location (UCSC)

Chr 1:
157.72 – 157.75 Mb

n/a

PubMed search

[1]

n/a

Fc receptor-like protein 2 is a protein that in humans is encoded by the FCRL2 gene.^[1]^[2]

References

^ Xu MJ, Zhao R, Zhao ZJ (Feb 2001). "Molecular cloning and characterization of SPAP1, an inhibitory receptor". Biochem Biophys Res Commun 280 (3): 768–75. doi:10.1006/bbrc.2000.4213. PMID 11162587.
^ "Entrez Gene: FCRL2 Fc receptor-like 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79368.

Davis RS, Wang YH, Kubagawa H, Cooper MD (2001). "Identification of a family of Fc receptor homologs with preferential B cell expression.". Proc. Natl. Acad. Sci. U.S.A. 98 (17): 9772–7. doi:10.1073/pnas.171308498. PMC 55528. PMID 11493702. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=55528.
Miller I, Hatzivassiliou G, Cattoretti G, et al. (2002). "IRTAs: a new family of immunoglobulinlike receptors differentially expressed in B cells.". Blood 99 (8): 2662–9. doi:10.1182/blood.V99.8.2662. PMID 11929751.
Guselnikov SV, Ershova SA, Mechetina LV, et al. (2002). "A family of highly diverse human and mouse genes structurally links leukocyte FcR, gp42 and PECAM-1.". Immunogenetics 54 (2): 87–95. doi:10.1007/s00251-002-0436-x. PMID 12037601.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=403697.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2286551.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Taylor AI, Gould HJ, Sutton BJ, Calvert RA (2007). "The first avian Ig-like Fc receptor family member combines features of mammalian FcR and FCRL.". Immunogenetics 59 (4): 323–8. doi:10.1007/s00251-007-0195-9. PMID 17273841.

FCRL2

References

Further reading