FCGR3A

Fc fragment of IgG, low affinity IIIa, receptor (CD16a)

PDB rendering based on 1e4j.

Available structures
PDB	1e4j, 1e4k, 1fnl, 1iis, 1iix, 1t83, 1t89

Identifiers

Symbols

FCGR3A; CD16; CD16A; FCG3; FCGR3; FCGRIII; FCR-10; FCRIII; FCRIIIA; IGFR3

External IDs

OMIM: 146740 MGI: 2179523 HomoloGene: 477 GeneCards: FCGR3A Gene

Gene Ontology
Molecular function	• receptor activity • IgG binding
Cellular component	• extracellular region • plasma membrane • integral to membrane
Biological process	• immune response • regulation of immune response
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
161.51 – 161.6 Mb

Chr 1:
172.95 – 172.96 Mb

PubMed search

[1]

[2]

Low affinity immunoglobulin gamma Fc region receptor III-A is a protein that in humans is encoded by the FCGR3A gene.^[1]^[2] It is also known as CD16a as it is part of the cluster of differentiation cell surface molecules.

References

^ Qiu WQ, de Bruin D, Brownstein BH, Pearse R, Ravetch JV (Jun 1990). "Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination". Science 248 (4956): 732–5. doi:10.1126/science.2139735. PMID 2139735.
^ "Entrez Gene: FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2214.

Anderson P, Caligiuri M, O'Brien C et al. (1990). "Fc gamma receptor type III (CD16) is included in the zeta NK receptor complex expressed by human natural killer cells". Proc. Natl. Acad. Sci. U.S.A. 87 (6): 2274–8. doi:10.1073/pnas.87.6.2274. PMC 53669. PMID 2138330. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=53669.
Le Coniat M, Kinet JP, Berger R (1990). "The human genes for the alpha and gamma subunits of the mast cell receptor for immunoglobulin E are located on human chromosome band 1q23". Immunogenetics 32 (3): 183–6. doi:10.1007/BF02114971. PMID 2146219.
Ory PA, Clark MR, Kwoh EE et al. (1989). "Sequences of complementary DNAs that encode the NA1 and NA2 forms of Fc receptor III on human neutrophils". J. Clin. Invest. 84 (5): 1688–91. doi:10.1172/JCI114350. PMC 304039. PMID 2478590. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=304039.
Peltz GA, Grundy HO, Lebo RV et al. (1989). "Human Fc gamma RIII: cloning, expression, and identification of the chromosomal locus of two Fc receptors for IgG". Proc. Natl. Acad. Sci. U.S.A. 86 (3): 1013–7. doi:10.1073/pnas.86.3.1013. PMC 286611. PMID 2521732. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=286611.
Scallon BJ, Scigliano E, Freedman VH et al. (1989). "A human immunoglobulin G receptor exists in both polypeptide-anchored and phosphatidylinositol-glycan-anchored forms". Proc. Natl. Acad. Sci. U.S.A. 86 (13): 5079–83. doi:10.1073/pnas.86.13.5079. PMC 297560. PMID 2525780. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=297560.
Ravetch JV, Perussia B (1989). "Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions". J. Exp. Med. 170 (2): 481–97. doi:10.1084/jem.170.2.481. PMC 2189395. PMID 2526846. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2189395.
Simmons D, Seed B (1988). "The Fc gamma receptor of natural killer cells is a phospholipid-linked membrane protein". Nature 333 (6173): 568–70. doi:10.1038/333568a0. PMID 2967436.
Indik ZK, Hunter S, Huang MM et al. (1994). "The high affinity Fc gamma receptor (CD64) induces phagocytosis in the absence of its cytoplasmic domain: the gamma subunit of Fc gamma RIIIA imparts phagocytic function to Fc gamma RI". Exp. Hematol. 22 (7): 599–606. PMID 7516890.
Detmers PA, Zhou D, Powell D et al. (1995). "Endotoxin receptors (CD14) are found with CD16 (Fc gamma RIII) in an intracellular compartment of neutrophils that contains alkaline phosphatase". J. Immunol. 155 (4): 2085–95. PMID 7543538.
Morcos M, Hänsch GM, Schönermark M et al. (1995). "Human glomerular mesangial cells express CD16 and may be stimulated via this receptor". Kidney Int. 46 (6): 1627–34. doi:10.1038/ki.1994.462. PMID 7700021.
Schumann G, Dasgupta JD (1995). "Specificity of signal transduction through CD16, TCR-CD3 and BCR receptor chains containing the tyrosine-associated activation motif". Int. Immunol. 6 (9): 1383–92. doi:10.1093/intimm/6.9.1383. PMID 7819147.
Gessner JE, Grussenmeyer T, Kolanus W, Schmidt RE (1995). "The human low affinity immunoglobulin G Fc receptor III-A and III-B genes. Molecular characterization of the promoter regions". J. Biol. Chem. 270 (3): 1350–61. doi:10.1074/jbc.270.3.1350. PMID 7836402.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Altin JG, Pagler EB, Kinnear BF, Warren HS (1994). "Molecular associations involving CD16, CD45 and zeta and gamma chains on human natural killer cells". Immunol. Cell Biol. 72 (1): 87–96. doi:10.1038/icb.1994.13. PMID 8157290.
Pignata C, Prasad KV, Robertson MJ et al. (1994). "Fc gamma RIIIA-mediated signaling involves src-family lck in human natural killer cells". J. Immunol. 151 (12): 6794–800. PMID 8258691.
Cone JC, Lu Y, Trevillyan JM et al. (1993). "Association of the p56lck protein tyrosine kinase with the Fc gamma RIIIA/CD16 complex in human natural killer cells". Eur. J. Immunol. 23 (10): 2488–97. doi:10.1002/eji.1830231017. PMID 8405050.
de Haas M, Koene HR, Kleijer M et al. (1996). "A triallelic Fc gamma receptor type IIIA polymorphism influences the binding of human IgG by NK cell Fc gamma RIIIa". J. Immunol. 156 (8): 3948–55. PMID 8609432.
Gessner JE, Grussenmeyer T, Dumbsky M, Schmidt RE (1997). "Separate promoters from proximal and medial control regions contribute to the natural killer cell-specific transcription of the human FcgammaRIII-A (CD16-A) receptor gene". J. Biol. Chem. 271 (48): 30755–64. doi:10.1074/jbc.271.48.30755. PMID 8940055.
Koene HR, Kleijer M, Algra J et al. (1997). "Fc gammaRIIIa-158V/F polymorphism influences the binding of IgG by natural killer cell Fc gammaRIIIa, independently of the Fc gammaRIIIa-48L/R/H phenotype". Blood 90 (3): 1109–14. PMID 9242542.

PDB gallery

1e4j: CRYSTAL STRUCTURE OF THE SOLUBLE HUMAN FC-GAMMA RECEPTOR III

1e4k: CRYSTAL STRUCTURE OF SOLUBLE HUMAN IGG1 FC FRAGMENT-FC-GAMMA RECEPTOR III COMPLEX

1fnl: CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF A HUMAN FCGRIII

1t83: CRYSTAL STRUCTURE OF A HUMAN TYPE III FC GAMMA RECEPTOR IN COMPLEX WITH AN FC FRAGMENT OF IGG1 (ORTHORHOMBIC)

1t89: CRYSTAL STRUCTURE OF A HUMAN TYPE III FC GAMMA RECEPTOR IN COMPLEX WITH AN FC FRAGMENT OF IGG1 (HEXAGONAL)

Proteins: clusters of differentiation (see also list of human clusters of differentiation)

1-50	CD1 (a-c, 1A, 1D, 1E) · CD2 · CD3 (γ, δ, ε) · CD4 · CD5 · CD6 · CD7 · CD8 (a) · CD9 · CD10 · CD11 (a, b, c) · CD13 · CD14 · CD15 · CD16 (A, B) · CD18 · CD19 · CD20 · CD21 · CD22 · CD23 · CD24 · CD25 · CD26 · CD27 · CD28 · CD29 · CD30 · CD31 · CD32 (A, B) · CD33 · CD34 · CD35 · CD36 · CD37 · CD38 · CD39 · CD40 · CD41 · CD42 (a, b, c, d) · CD43 · CD44 · CD45 · CD46 · CD47 · CD48 · CD49 (a, b, c, d, e, f) · CD50

51-100	CD51 · CD52 · CD53 · CD54 · CD55 · CD56 · CD57 · CD58 · CD59 · CD61 · CD62 (E, L, P) · CD63 · CD64 (A, B, C) · CD66 (a, b, c, d, e, f) · CD68 · CD69 · CD70 · CD71 · CD72 · CD73 · CD74 · CD78 · CD79 (a, b) · CD80 · CD81 · CD82 · CD83 · CD84 · CD85 (a, d, e, h, j, k) · CD86 · CD87 · CD88 · CD89 · CD90 · CD91- CD92 · CD93 · CD94 · CD95 · CD96 · CD97 · CD98 · CD99 · CD100

101-150	CD101 · CD102 · CD103 · CD104 · CD105 · CD106 · CD107 (a, b) · CD108 · CD109 · CD110 · CD111 · CD112 · CD113 · CD114 · CD115 · CD116 · CD117 · CD118 · CD119 · CD120 (a, b) · CD121 (a, b) · CD122 · CD123 · CD124 · CD125 · CD126 · CD127 · CD129 · CD130 · CD131 · CD132 · CD133 · CD134 · CD135 · CD136 · CD137 · CD138 · CD140b · CD141 · CD142 · CD143 · CD144 · CD146 · CD147 · CD148 · CD150

151-200	CD151 · CD152 · CD153 · CD154 · CD155 · CD156 (a, b, c) · CD157 · CD158 (a, d, e, i, k) · CD159 (a, c) · CD160 · CD161 · CD162 · CD163 · CD164 · CD166 · CD167 (a, b) · CD168 · CD169 · CD170 · CD171 · CD172 (a, b, g) · CD174 · CD177 · CD178 · CD179 (a, b) · CD181 · CD182 · CD183 · CD184 · CD185 · CD186 · CD191 · CD192 · CD193 · CD194 · CD195 · CD196 · CD197 · CDw198 · CDw199 · CD200

201-250	CD201 · CD202b · CD204 · CD205 · CD206 · CD207 · CD208 · CD209 · CDw210 (a, b) · CD212 · CD213a (1, 2) · CD217 · CD218 (a, b) · CD220 · CD221 · CD222 · CD223 · CD224 · CD225 · CD226 · CD227 · CD228 · CD229 · CD230 · CD233 · CD234 · CD235 (a, b) · CD236 · CD238 · CD239 · CD240CE · CD240D · CD241 · CD243 · CD244 · CD246 · CD247- CD248 · CD249

251-300	CD252 · CD253 · CD254 · CD256 · CD257 · CD258 · CD261 · CD262 · CD264 · CD265 · CD266 · CD267 · CD268 · CD269 · CD271 · CD272 · CD273 · CD274 · CD275 · CD276 · CD278 · CD279 · CD280 · CD281 · CD282 · CD283 · CD284 · CD286 · CD288 · CD289 · CD290 · CD292 · CDw293 · CD294 · CD295 · CD297 · CD298 · CD299

301-350	CD300A · CD301 · CD302 · CD303 · CD304 · CD305 · CD306 · CD307 · CD309 · CD312 · CD314 · CD315 · CD316 · CD317 · CD318 · CD320 · CD321 · CD322 · CD324 · CD325 · CD326 · CD328 · CD329 · CD331 · CD332 · CD333 · CD334 · CD335 · CD336 · CD337 · CD338 · CD339 · CD340 · CD344 · CD349 · CD350

FCGR3A

References

Further reading