FBXO4

F-box protein 4

Rendering based on PDB 3L2O.
Identifiers
Symbols FBXO4; DKFZp547N213; FBX4; FLJ10141
External IDs OMIM609090 MGI2146220 HomoloGene8134 GeneCards: FBXO4 Gene
Orthologs
Species Human Mouse
Entrez 26272 106052
Ensembl ENSG00000151876 ENSMUSG00000022184
UniProt Q9UKT5 Q8CHQ0
RefSeq (mRNA) NM_012176.2 NM_134099.2
RefSeq (protein) NP_036308.1 NP_598860.2
Location (UCSC) Chr 5:
41.93 – 41.94 Mb
Chr 15:
3.92 – 3.93 Mb
PubMed search [1] [2]

F-box only protein 4 is a protein that in humans is encoded by the FBXO4 gene.[1][2][3]

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants.[3]

Interactions

FBXO4 has been shown to interact with SKP1A[4][1] and CUL1.[4][1]

References

  1. ^ a b c Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins". Curr Biol 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035. 
  2. ^ Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW (Dec 1999). "A family of mammalian F-box proteins". Curr Biol 9 (20): 1180–2. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037. 
  3. ^ a b "Entrez Gene: FBXO4 F-box protein 4". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26272. 
  4. ^ a b Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948. 

Further reading