FBXL3

F-box and leucine-rich repeat protein 3
Identifiers
Symbols FBXL3; FBL3; FBL3A; FBXL3A
External IDs OMIM: 605653 MGI: 1354702 HomoloGene: 8127 GeneCards: FBXL3 Gene
Orthologs
Species Human Mouse
Entrez 26224 50789
Ensembl ENSG00000005812 ENSMUSG00000022124
UniProt Q9UKT7 Q3TJJ7
RefSeq (mRNA) NM_012158.2 NM_015822.2
RefSeq (protein) NP_036290.1 NP_056637.1
Location (UCSC) Chr 13:
77.57 – 77.6 Mb		 Chr 14:
103.48 – 103.5 Mb
PubMed search [1] [2]

F-box/LRR-repeat protein 3 is a protein that in humans is encoded by the FBXL3 gene.[1][2]

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD40 repeats, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats and is localized in the nucleus.[3]

Interactions

FBXL3 has been shown to interact with SKP1A.[1]

References

  1. ^ a b Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins". Curr Biol 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035. 
  2. ^ Chiaur DS, Murthy S, Cenciarelli C, Parks W, Loda M, Inghirami G, Demetrick D, Pagano M (Jun 2000). "Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumors". Cytogenet Cell Genet 88 (3-4): 255–8. doi:10.1159/000015532. PMID 10828603. 
  3. ^ "Entrez Gene: FBXL3 F-box and leucine-rich repeat protein 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26224. 

Further reading