FAT4

FAT tumor suppressor homolog 4 (Drosophila)

Identifiers

FAT4; CDHF14; CDHR11; FAT-J; FATJ; FLJ23056; FLJ77878; NBLA00548

External IDs

OMIM: 612411 MGI: 3045256 HomoloGene: 14377 GeneCards: FAT4 Gene

Gene Ontology
Molecular function	• calcium ion binding
Cellular component	• plasma membrane • integral to membrane
Biological process	• cell adhesion • homophilic cell adhesion
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 4:
126.24 – 126.41 Mb

Chr 3:
38.79 – 38.91 Mb

PubMed search

[1]

[2]

Protocadherin Fat 4, also known as cadherin family member 14 (CDHF14) or FAT tumor suppressor homolog 4 (FAT4), is a protein that in humans is encoded by the FAT4 gene.^[1]^[2]

FAT4 is associated with the Hippo signaling pathway.^[3]

References

^ "Entrez Gene: FAT tumor suppressor homolog 4 (Drosophila)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79633.
^ Höng JC, Ivanov NV, Hodor P, Xia M, Wei N, Blevins R, Gerhold D, Borodovsky M, Liu Y (March 2004). "Identification of new human cadherin genes using a combination of protein motif search and gene finding methods". J. Mol. Biol. 337 (2): 307–17. doi:10.1016/j.jmb.2004.01.026. PMID 15003449.
^ Qi C, Zhu YT, Hu L, Zhu YJ (February 2009). "Identification of Fat4 as a candidate tumor suppressor gene in breast cancers". Int. J. Cancer 124 (4): 793–8. doi:10.1002/ijc.23775. PMC 2667156. PMID 19048595. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2667156.

Katoh Y, Katoh M (2006). "Comparative integromics on FAT1, FAT2, FAT3 and FAT4.". Int. J. Mol. Med. 18 (3): 523–8. PMID 16865240.
Caporaso N, Gu F, Chatterjee N, et al. (2009). Reitsma, Pieter H.. ed. "Genome-wide and candidate gene association study of cigarette smoking behaviors.". PLoS ONE 4 (2): e4653. doi:10.1371/journal.pone.0004653. PMC 2644817. PMID 19247474. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2644817.
Liu Y, Blackwood DH, Caesar S, et al. (2010). "Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder". Molecular psychiatry 16 (1): HASH(0x11aa390). doi:10.1038/mp.2009.107. PMID 20351715.
Need AC, Attix DK, McEvoy JM, et al. (2009). "A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB". Hum. Mol. Genet. 18 (23): 4650–61. doi:10.1093/hmg/ddp413. PMC 2773267. PMID 19734545. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2773267.
Rose JE, Behm FM, Drgon T, et al. (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2896464.
Ballif BA, VillÃ©n J, Beausoleil SA, et al. (2004). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell Proteomics 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Johnson AD, Kavousi M, Smith AV, et al. (2009). "Genome-wide association meta-analysis for total serum bilirubin levels". Hum. Mol. Genet. 18 (14): 2700–10. doi:10.1093/hmg/ddp202. PMC 2701336. PMID 19414484. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2701336.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.

Signaling pathway: Hippo signaling pathway

Receptor	FAT4

Adaptor protein	NF2 · FRMD6 · SAV1 · MOBKL1A, MOBKL1B

Kinase	MST1, MST2 · LATS1, LATS2

Transcription factor	YAP1, TAZ

Other/unknown	RASSF1

B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

FAT4

References

Further reading