Erbin (protein)

Erbb2 interacting protein

PDB rendering based on 1mfg.
Identifiers
Symbols ERBB2IP; ERBIN; LAP2
External IDs OMIM: 606944 MGI: 1890169 HomoloGene: 41282 GeneCards: ERBB2IP Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 55914 59079
Ensembl ENSG00000112851 ENSMUSG00000021709
UniProt Q96RT1 Q80TH2
RefSeq (mRNA) NM_001006600.1 NM_001005868
RefSeq (protein) NP_001006600.1 NP_001005868
Location (UCSC) Chr 5:
65.22 – 65.38 Mb		 Chr 13:
104.61 – 104.71 Mb
PubMed search [1] [2]

Erbb2 interacting protein (ERBB2IP) also known as Erbin is a protein which in humans is encoded by the ERBB2IP gene.[1] Discovered in 1997, Erbin is a 200kDa protein containing a PDZ domain.[2]

Contents

Function

This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternate transcriptional splice variants encoding different isoforms have been found for this gene, but only two of them have been characterized to date.[1]

Clinical significance

Erbin's C-terminal PDZ domain is able to bind to ErbB2, a protein tyrosine kinase which is often associated with poor prognosis in epidermal oncogenesis.[3] Erbin's N-terminal region has been shown to disrupt Ras to Raf binding and may be, through this action, a tumor suppressing protein.[4]

Interactions

Erbin (protein) has been shown to interact with HER2/neu,[5][6][7] Dystonin,[8] PKP4,[9][10][11] Mothers against decapentaplegic homolog 3[12] and ITGB4.[8]

References

  1. ^ a b "Entrez Gene: ERBB2IP erbb2 interacting protein". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55914. 
  2. ^ Borg JP, Marchetto S. et al. (2000). "ERBIN: a basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor". Nat. Cell. Biol. 2 (7): 407–414. doi:10.1038/35017038. PMID 10878805. 
  3. ^ Kolch, W. (2003). "Erbin: sorting out ErbB2 receptors or giving Ras a break?". Sci. STKE. 2003 (199): pe37. doi:10.1126/stke.2003.199.pe37. PMID 12966186. 
  4. ^ Dai P, Xiong WC, and Mei L. (2006). "Erbin inhibits RAF activation by disrupting the sur-8-Ras-Raf complex". J. Biol. Chem. 281 (2): 927–933. doi:10.1074/jbc.M507360200. PMID 16301319. 
  5. ^ Jaulin-Bastard, F; Saito H, Le Bivic A, Ollendorff V, Marchetto S, Birnbaum D, Borg J P (May. 2001). "The ERBB2/HER2 receptor differentially interacts with ERBIN and PICK1 PSD-95/DLG/ZO-1 domain proteins". J. Biol. Chem. (United States) 276 (18): 15256–63. doi:10.1074/jbc.M010032200. ISSN 0021-9258. PMID 11278603. 
  6. ^ Borg, J P; Marchetto S, Le Bivic A, Ollendorff V, Jaulin-Bastard F, Saito H, Fournier E, Adélaïde J, Margolis B, Birnbaum D (Jul. 2000). "ERBIN: a basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor". Nat. Cell Biol. (ENGLAND) 2 (7): 407–14. doi:10.1038/35017038. ISSN 1465-7392. PMID 10878805. 
  7. ^ Huang, Yang Z; Zang Mengwei, Xiong Wen C, Luo Zhijun, Mei Lin (Jan. 2003). "Erbin suppresses the MAP kinase pathway". J. Biol. Chem. (United States) 278 (2): 1108–14. doi:10.1074/jbc.M205413200. ISSN 0021-9258. PMID 12379659. 
  8. ^ a b Favre, B; Fontao L, Koster J, Shafaatian R, Jaunin F, Saurat J H, Sonnenberg A, Borradori L (Aug. 2001). "The hemidesmosomal protein bullous pemphigoid antigen 1 and the integrin beta 4 subunit bind to ERBIN. Molecular cloning of multiple alternative splice variants of ERBIN and analysis of their tissue expression". J. Biol. Chem. (United States) 276 (35): 32427–36. doi:10.1074/jbc.M011005200. ISSN 0021-9258. PMID 11375975. 
  9. ^ Izawa, Ichiro; Nishizawa Miwako, Tomono Yasuko, Ohtakara Kazuhiro, Takahashi Toshitada, Inagaki Masaki (May. 2002). "ERBIN associates with p0071, an armadillo protein, at cell-cell junctions of epithelial cells". Genes Cells (England) 7 (5): 475–85. doi:10.1046/j.1365-2443.2002.00533.x. ISSN 1356-9597. PMID 12047349. 
  10. ^ Jaulin-Bastard, Fanny; Arsanto Jean-Pierre, Le Bivic André, Navarro Christel, Vély Frederic, Saito Hiroko, Marchetto Sylvie, Hatzfeld Mechthild, Santoni Marie-Josée, Birnbaum Daniel, Borg Jean-Paul (Jan. 2002). "Interaction between Erbin and a Catenin-related protein in epithelial cells". J. Biol. Chem. (United States) 277 (4): 2869–75. doi:10.1074/jbc.M109652200. ISSN 0021-9258. PMID 11711544. 
  11. ^ Laura, Richard P; Witt Andrea S, Held Heike A, Gerstner Resi, Deshayes Kurt, Koehler Michael F T, Kosik Kenneth S, Sidhu Sachdev S, Lasky Laurence A (Apr. 2002). "The Erbin PDZ domain binds with high affinity and specificity to the carboxyl termini of delta-catenin and ARVCF". J. Biol. Chem. (United States) 277 (15): 12906–14. doi:10.1074/jbc.M200818200. ISSN 0021-9258. PMID 11821434. 
  12. ^ Warner, Dennis R; Pisano M Michele, Roberts Emily A, Greene Robert M (Mar. 2003). "Identification of three novel Smad binding proteins involved in cell polarity". FEBS Lett. (Netherlands) 539 (1–3): 167–73. doi:10.1016/S0014-5793(03)00155-8. ISSN 0014-5793. PMID 12650946. 

Further reading