Epoxomicin

Epoxomicin^[1]

IUPAC name (2S,3S)-N-((2S,3R)-3-hydroxy-1-(((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)amino)-1-oxobutan-2-yl)-3-methyl-2-((2S,3S)-3-methyl-2-(N-methylacetamido)pentanamido)pentanamide
Other names BU 4061T
Identifiers
CAS number	134381-21-8^Y
PubChem	3035402
ChEMBL	CHEMBL207990^N
Jmol-3D images	Image 1
SMILES O=C([C@@]1(C)CO1)[C@H](CC(C)C)NC([C@@H](NC([C@H]([C@@H](C)CC)NC([C@H]([C@@H](C)CC)N(C)C(C)=O)=O)=O)[C@H](O)C)=O
Properties
Molecular formula	C₂₈H₅₀N₄O₇
Molar mass	554.72 g mol⁻¹
Appearance	White solid
Solubility in DMSO	10 mg/mL
N (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Epoxomicin is a naturally occurring selective proteasome inhibitor with anti-inflammatory activity.^[2] It was originally discovered in 1992.^[3] Injected, it can induce Parkinson's-like symptoms in rats.

Derivatives of epoxomicin include carfilzomib.

References