Epi-lipoxin

Epi-lipoxins are the 5R-epimers of lipoxins. These nonclassic eicosanoids are formed in vivo, in the presence of aspirin.[1] They play a counter-regulatory role in inflammation, serving as a stop signal.[2]

References

  1. ^ Clària J, Serhan CN (1995). "Aspirin triggers previously undescribed bioactive eicosanoids by human endothelial cell-leukocyte interactions". Proc. Natl. Acad. Sci. U.S.A. 92 (21): 9475–9. doi:10.1073/pnas.92.21.9475. PMC 40824. PMID 7568157. http://www.pnas.org/cgi/reprint/92/21/9475. Retrieved 2007-11-01. 
  2. ^ Serhan CN (2001). "Lipoxins and aspirin-triggered 15-epi-lipoxins are endogenous components of antiinflammation: emergence of the counterregulatory side". Arch. Immunol. Ther. Exp. (Warsz.) 49 (3): 177–88. PMID 11478391. 
Precursor
Prostanoids
Precursor
Active
D/J
E/F
I
A2 · B2
Leukotrienes (LT)
Precursor
Initial
A4 · B4
C4 · D4 · E4
Nonclassic
By function

bronchoconstriction (PGF2α, TXA2, LTC4, LTD4, LTE4)

vasoconstriction (PGF2α, TXA2, TXB2) · vasodilation (PGE2, PGI2, LTC4, LTD4, LTE4)

platelets: induce (TXA2) inhibit (PGD2, PGI2) · leukocytes: induce (TXA2, LTB4) inhibit (PGD2, PGE2)

fever stimulation: (PGE2)

labor stimulation: (PGE2 (Dinoprostone), PGF2α (Dinoprost))

M: MET

mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m

k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon

m(A16/C10),i(k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)
biochemical families: prot · nucl · carb (glpr, alco, glys) · lipd (fata/i, phld, strd, gllp, eico) · amac/i · ncbs/i · ttpy/i