Eomesodermin

Identifiers

External IDs

OMIM: 604615 HomoloGene: 3971 GeneCards: EOMES Gene

Gene Ontology
Molecular function	• DNA binding • sequence-specific DNA binding transcription factor activity • sequence-specific DNA binding
Cellular component	• intracellular • nucleus
Biological process	• endoderm formation • mesoderm formation • blastocyst development • trophectodermal cell differentiation • CD8-positive, alpha-beta T cell differentiation involved in immune response • multicellular organismal development • brain development • cerebral cortex neuron differentiation • positive regulation of cell differentiation • positive regulation of transcription, DNA-dependent • positive regulation of transcription from RNA polymerase II promoter • cell differentiation involved in embryonic placenta development • mesodermal to mesenchymal transition involved in gastrulation
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

n/a

RefSeq (protein)

NP_005433.2

n/a

Location (UCSC)

Chr 3:
27.76 – 27.76 Mb

Chr 9:
118.39 – 118.4 Mb

PubMed search

[1]

[2]

Eomesodermin also known as T-box brain protein 2 (TBR2) is a protein that in humans is encoded by the EOMES gene.^[1]

This gene encodes a member of a conserved protein family that shares a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. A similar gene disrupted in mice is shown to be essential during trophoblast development and gastrulation.^[1]

References

^ ^a ^b "Entrez Gene: Eomesodermin". http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&list_uids=8320. Retrieved 2011-11-01T22:27:07.474-07:00.

Kimura, N.; Nakashima, K.; Ueno, M.; Kiyama, H.; Taga, T. (1999). "A novel mammalian T-box-containing gene, Tbr2, expressed in mouse developing brain". Brain research. Developmental brain research 115 (2): 183–193. PMID 10407135. edit
Intlekofer, A. M.; Takemoto, N.; Wherry, E. J.; Longworth, S. A.; Northrup, J. T.; Palanivel, V. R.; Mullen, A. C.; Gasink, C. R. et al. (2005). "Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin". Nature Immunology 6 (12): 1236–1244. doi:10.1038/ni1268. PMID 16273099. edit
Baala, L.; Briault, S.; Etchevers, H. C.; Laumonnier, F. D. R.; Natiq, A.; Amiel, J.; Boddaert, N.; Picard, C. et al. (2007). "Homozygous silencing of T-box transcription factor EOMES leads to microcephaly with polymicrogyria and corpus callosum agenesis". Nature Genetics 39 (4): 454–456. doi:10.1038/ng1993. PMID 17353897. edit
Atreya, I.; Schimanski, C. C.; Becker, C.; Wirtz, S.; Dornhoff, H.; Schnurer, E.; Berger, M. R.; Galle, P. R. et al. (2007). "The T‐box transcription factor eomesodermin controls CD8 T cell activity and lymph node metastasis in human colorectal cancer". Gut 56 (11): 1572–1578. doi:10.1136/gut.2006.117812. PMC 2095672. PMID 17566017. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2095672. edit
Araki, Y.; Fann, M.; Wersto, R.; Weng, N. P. (2008). "Histone Acetylation Facilitates Rapid and Robust Memory CD8 T Cell Response through Differential Expression of Effector Molecules (Eomesodermin and Its Targets: Perforin and Granzyme B)". Journal of immunology (Baltimore, Md. : 1950) 180 (12): 8102–8108. PMC 2493419. PMID 18523274. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2493419. edit
Sessa, A.; Mao, C. A.; Hadjantonakis, A. K.; Klein, W. H.; Broccoli, V. (2008). "Tbr2 Directs Conversion of Radial Glia into Basal Precursors and Guides Neuronal Amplification by Indirect Neurogenesis in the Developing Neocortex". Neuron 60 (1): 56–69. doi:10.1016/j.neuron.2008.09.028. PMC 2887762. PMID 18940588. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2887762. edit
d’Cruz, L. M.; Rubinstein, M. P.; Goldrath, A. W. (2009). "Surviving the crash: Transitioning from effector to memory CD8+ T cell". Seminars in Immunology 21 (2): 92–98. doi:10.1016/j.smim.2009.02.002. PMC 2671236. PMID 19269192. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2671236. edit
Wang, H. T.; Ge, X. S.; Xue, Z. P.; Li, B. Q. (2010). "Role of transcription factor T-bet and Eomes in IFN-gamma secretion of different human T cell subsets". Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 26 (1): 31–34. PMID 20056084. edit
Narayanan, S.; Silva, R.; Peruzzi, G.; Alvarez, Y.; Simhadri, V. R.; Debell, K.; Coligan, J. E.; Borrego, F. (2010). Unutmaz, Derya. ed. "Human Th1 Cells That Express CD300a Are Polyfunctional and After Stimulation Up-Regulate the T-Box Transcription Factor Eomesodermin". PLoS ONE 5 (5): e10636. doi:10.1371/journal.pone.0010636. PMC 2869357. PMID 20498708. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2869357. edit
Kinjyo, I.; Gordon, S. M.; Intlekofer, A. M.; Dowdell, K.; Mooney, E. C.; Caricchio, R.; Grupp, S. A.; Teachey, D. T. et al. (2010). "Lymphoproliferation Caused by Fas Deficiency is Dependent on the Transcription Factor Eomesodermin". The Journal of Immunology 185 (12): 7151–7155. doi:10.4049/jimmunol.1003193. PMC 2997140. PMID 21076068. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2997140. edit

Transcription factors and intracellular receptors

(1) Basic domains

(1.1) Basic leucine zipper (bZIP)	Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) · AP-1 (c-Fos, FOSB, FOSL1, FOSL2, JDP2, c-Jun, JUNB, JUND) · BACH (1, 2) · BATF · BLZF1 · C/EBP (α, β, γ, δ, ε, ζ) · CREB (1, 3, L1) · CREM · DBP · DDIT3 · GABPA · HLF · MAF (B, F, G, K) · NFE (2, L1, L2, L3) · NFIL3 · NRL · NRF (1, 2, 3) · XBP1

(1.2) Basic helix-loop-helix (bHLH)	ATOH1 · AhR · AHRR · ARNT · ASCL1 · BHLHB2 · BMAL (ARNTL, ARNTL2) · CLOCK · EPAS1 · FIGLA · HAND (1, 2) · HES (5, 6) · HEY (1, 2, L) · HES1 · HIF (1A, 3A) · ID (1, 2, 3, 4) · LYL1 · MESP2 · MXD4 · MYCL1 · MYCN · Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) · Neurogenins (1, 2, 3) · NeuroD (1, 2) · NPAS (1, 2, 3) · OLIG (1, 2) · Pho4 · Scleraxis · SIM (1, 2) · TAL (1, 2) · Twist · USF1

(1.3) bHLH-ZIP	AP-4 · MAX · MITF · MNT · MLX · MXI1 · Myc · SREBP (1, 2)

(1.4) NF-1	NFI (A, B, C, X) · SMAD (R-SMAD (1, 2, 3, 5, 9) - I-SMAD (6, 7) - 4)

(1.5) RF-X	RFX (1, 2, 3, 4, 5, ANK)

(1.6) Basic helix-span-helix (bHSH)	AP-2 (α, β, γ, δ, ε)

(2) Zinc finger DNA-binding domains

(2.1) Nuclear receptor (Cys₄)	subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) subfamily 3 (Steroid hormone (Androgen, Estrogen (α, β), Glucocorticoid, Mineralocorticoid, Progesterone), Estrogen related (α, β, γ)) subfamily 4 NUR (NGFIB, NOR1, NURR1) · subfamily 5 (LRH-1, SF1) · subfamily 6 (GCNF) · subfamily 0 (DAX1, SHP)

(2.2) Other Cys₄	GATA (1, 2, 3, 4, 5, 6) · MTA (1, 2, 3) · TRPS1

(2.3) Cys₂His₂	General transcription factors (TFIIA, TFIIB, TFIID, TFIIE (1, 2), TFIIF (1, 2), TFIIH (1, 2, 4, 2I, 3A, 3C1, 3C2)) ATBF1 · BCL (6, 11A, 11B) · CTCF · E4F1 · EGR (1, 2, 3, 4) · ERV3 · GFI1 · GLI-Krüppel family (1, 2, 3, REST, S2, YY1) · HIC (1, 2) · HIVEP (1, 2, 3) · IKZF (1, 2, 3) · ILF (2, 3) · KLF (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 17) · MTF1 · MYT1 · OSR1 · PRDM9 · SALL (1, 2, 3, 4) · SP (1, 2, 4, 7, 8) · TSHZ3 · WT1 · Zbtb7 (7A, 7B) · ZBTB (16, 17, 20, 32, 33, 40) · zinc finger (3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 300, 318, 330, 346, 350, 365, 366, 384, 423, 451, 452, 471, 593, 638, 644, 649, 655)

(2.4) Cys₆	HIVEP1

(2.5) Alternating composition	AIRE · DIDO1 · GRLF1 · ING (1, 2, 4) · JARID (1A, 1B, 1C, 1D, 2) · JMJD1B

(3) Helix-turn-helix domains

(3.1) Homeodomain	ARX · CDX (1, 2) · CRX · CUTL1 · DBX (1, 2) · DLX (3, 4, 5) · EMX2 · EN (1, 2) · FHL (1, 2, 3) · HESX1 · HHEX · HLX · Homeobox (A1, A2, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C12, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) · HOPX · IRX (1, 2, 3, 4, 5, 6, MKX) · LMX (1A, 1B) · MEIS (1, 2) · MEOX2 · MNX1 · MSX (1, 2) · NANOG · NKX (2-1, 2-2, 2-3, 2-5, 3-1, 3-2, 6-1, 6-2) · NOBOX · PBX (1, 2, 3) · PHF (1, 3, 6, 8, 10, 16, 17, 20, 21A) · PHOX (2A, 2B) · PITX (1, 2, 3) · POU domain (PIT-1, BRN-3: A, B, C, Octamer transcription factor: 1, 2, 3/4, 6, 7, 11) · OTX (1, 2) · PDX1 · SATB2 · SHOX2 · VAX1 · ZEB (1, 2)

(3.2) Paired box	PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)

(3.3) Fork head / winged helix	E2F (1, 2, 3, 4, 5) · FOX proteins (A1, A2, A3, C1, C2, D3, D4, E1, E3, F1, G1, H1, I1, J1, J2, K1, K2, L2, M1, N1, N3, O1, O3, O4, P1, P2, P3, P4)

(3.4) Heat Shock Factors	HSF (1, 2, 4)

(3.5) Tryptophan clusters	ELF (2, 4, 5) · EGF · ELK (1, 3, 4) · ERF · ETS (1, 2, ERG, SPIB) · ETV (1, 4, 5, 6) · FLI1 · Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) · MYB · MYBL2

(3.6) TEA domain	transcriptional enhancer factor (1, 2, 3, 4)

(4) β-Scaffold factors with minor groove contacts

(4.1) Rel homology region	NF-κB (NFKB1, NFKB2, REL, RELA, RELB) · NFAT (C1, C2, C3, C4, 5)

(4.2) STAT	STAT (1, 2, 3, 4, 5, 6)

(4.3) p53	p53 · TBX (1, 2, 3, 5, 19, 21, 22, Brachyury, TBR1, TBR2) · TP63

(4.4) MADS box	Mef2 (A, B, C, D) · SRF

(4.6) TATA binding proteins	TBP · TBPL1

(4.7) High-mobility group	BBX · HMGB (1, 2, 3, 4) · HMGN (1, 2, 3, 4) · HNF (1A, 1B) · LEF1 · SOX (1, 2, 3, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14, 15, 18, 21) · SRY · SSRP1 · TCF (3, 4) · TOX (1, 2, 3, 4)

(4.10) Cold-shock domain	CSDA, YBX1

(4.11) Runt	CBF (CBFA2T2, CBFA2T3, RUNX1, RUNX2, RUNX3, RUNX1T1)

(0) Other transcription factors

(0.2) HMGI(Y)	HMGA (1, 2) · HBP1

(0.3) Pocket domain	Rb · RBL1 · RBL2

(0.5) AP-2/EREBP-related factors	Apetala 2 · EREBP · B3

(0.6) Miscellaneous	ARID (1A, 1B, 2, 3A, 3B, 4A) · CAP · IFI (16, 35) · MLL (2, 3, T1) · MNDA · NFY (A, B, C) · Rho/Sigma

see also transcription factor/coregulator deficiencies
B bsyn: dna (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Eomesodermin

See also

References

Further reading