Ebselen

Ebselen
IUPAC name

2-Phenyl-1,2-benzoselenazol-3-one
Identifiers
CAS number 60940-34-3
PubChem 3194
ChemSpider 3082 Y
ChEMBL CHEMBL51085 Y
Jmol-3D images Image 1
Image 2
Properties
Molecular formula C13H9NOSe
Molar mass 274.17666
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Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Ebselen or 2-phenyl-1, 2-benzisoselenazol-3(2H)-one (also called PZ 51 or DR3305), is a mimic of glutathione peroxidase and can also react with peroxynitrite.[1] It is being investigated as a possible treatment for reperfusion injury and stroke,[2][3] as well as tinnitus.[4]

Ebselen is a potent scavenger of hydrogen peroxide as well as hydroperoxides including membrane bound phospholipid and cholesterylester hydroperoxides.

References

  1. ^ Schewe T (1995). "Molecular actions of ebselen--an antiinflammatory antioxidant". Gen Pharmacol 26 (6): 1153–69. doi:10.1016/0306-3623(95)00003-J. PMID 7590103. 
  2. ^ Parnham M, Sies H (2000). "Ebselen: prospective therapy for cerebral ischaemia". Expert Opin Investig Drugs 9 (3): 607–19. doi:10.1517/13543784.9.3.607. PMID 11060699. 
  3. ^ Yamaguchi T, Sano K, Takakura K, Saito I, Shinohara Y, Asano T, Yasuhara H (1 January 1998). "Ebselen in acute ischemic stroke: a placebo-controlled, double-blind clinical trial. Ebselen Study Group". Stroke 29 (1): 12–7. doi:10.1161/01.STR.29.1.12. PMID 9445321. http://stroke.ahajournals.org/cgi/content/full/29/1/12. 
  4. ^ Kil, Jonathan; Pierce, Carol; Tran, Huy; Gu, Rende; Lynch, Eric D (2007). "Ebselen treatment reduces noise induced hearing loss via the mimicry and induction of glutathione peroxidase". Hearing Research 226 (1–2): 44–51. doi:10.1016/j.heares.2006.08.006. PMID 17030476.