ERVK6

Endogenous retrovirus group K, member 6

Identifiers

ERVK-6; ERVK6; HERV-K(C7); HERV-K108; K-Rev; c-orf; cORF

External IDs

Gene Ontology
Molecular function	• nucleic acid binding • DNA binding • RNA binding • DNA-directed DNA polymerase activity • RNA-directed DNA polymerase activity • aspartic-type endopeptidase activity • endonuclease activity • ribonuclease H activity • structural molecule activity • peptidase activity • zinc ion binding • integrase activity • transferase activity • nucleotidyltransferase activity • hydrolase activity • metal ion binding
Cellular component	• intracellular • nucleus • nucleolus • cytoplasm • plasma membrane • integral to membrane • virion • viral capsid • viral envelope
Biological process	• RNA-dependent DNA replication • DNA recombination • proteolysis • transport • DNA integration • viral reproduction • dUTP metabolic process • mRNA transport

Orthologs

Species

Human

Mouse

n/a

n/a

n/a

RefSeq (mRNA)

NM_001007236

n/a

RefSeq (protein)

NP_001007237

n/a

Location (UCSC)

n/a

PubMed search

[1]

n/a

HERV-K_19q12 provirus ancestral Pol protein is a protein that in humans is encoded by the ERVK6 gene.^[1]^[2]^[3]

References

^ Mayer J, Sauter M, Racz A, Scherer D, Mueller-Lantzsch N, Meese E (Mar 1999). "An almost-intact human endogenous retrovirus K on human chromosome 7". Nat Genet 21 (3): 257–8. doi:10.1038/6766. PMID 10080172.
^ Reus K, Mayer J, Sauter M, Scherer D, Muller-Lantzsch N, Meese E (Jun 2001). "Genomic organization of the human endogenous retrovirus HERV-K(HML-2.HOM) (ERVK6) on chromosome 7". Genomics 72 (3): 314–20. doi:10.1006/geno.2000.6488. PMID 11401447.
^ "Entrez Gene: ERVK6 endogenous retroviral sequence K, 6". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64006.

Löwer R, Tönjes RR, Korbmacher C, et al. (1995). "Identification of a Rev-related protein by analysis of spliced transcripts of the human endogenous retroviruses HTDV/HERV-K.". J. Virol. 69 (1): 141–9. PMC 188557. PMID 7983704. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=188557.
Sauter M, Schommer S, Kremmer E, et al. (1995). "Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas.". J. Virol. 69 (1): 414–21. PMC 188589. PMID 7983737. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=188589.
Zsíros J, Jebbink MF, Lukashov VV, et al. (1998). "Evolutionary relationships within a subgroup of HERV-K-related human endogenous retroviruses.". J. Gen. Virol.. 79 ( Pt 1): 61–70. PMID 9460924.
Andersson ML, Lindeskog M, Medstrand P, et al. (1999). "Diversity of human endogenous retrovirus class II-like sequences.". J. Gen. Virol.. 80 ( Pt 1): 255–60. PMID 9934709.
Berkhout B, Jebbink M, Zsíros J (1999). "Identification of an active reverse transcriptase enzyme encoded by a human endogenous HERV-K retrovirus.". J. Virol. 73 (3): 2365–75. PMC 104482. PMID 9971820. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=104482.
Barbulescu M, Turner G, Seaman MI, et al. (1999). "Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.". Curr. Biol. 9 (16): 861–8. doi:10.1016/S0960-9822(99)80390-X. PMID 10469592.
Tönjes RR, Czauderna F, Kurth R (1999). "Genome-wide screening, cloning, chromosomal assignment, and expression of full-length human endogenous retrovirus type K.". J. Virol. 73 (11): 9187–95. PMC 112952. PMID 10516026. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=112952.
Sugimoto J, Matsuura N, Kinjo Y, et al. (2001). "Transcriptionally active HERV-K genes: identification, isolation, and chromosomal mapping.". Genomics 72 (2): 137–44. doi:10.1006/geno.2001.6473. PMID 11401426.
Wang-Johanning F, Frost AR, Jian B, et al. (2003). "Quantitation of HERV-K env gene expression and splicing in human breast cancer.". Oncogene 22 (10): 1528–35. doi:10.1038/sj.onc.1206241. PMID 12629516.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
de Parseval N, Lazar V, Casella JF, et al. (2003). "Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins.". J. Virol. 77 (19): 10414–22. doi:10.1128/JVI.77.19.10414-10422.2003. PMC 228468. PMID 12970426. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=228468.
Blaise S, de Parseval N, Bénit L, Heidmann T (2004). "Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.". Proc. Natl. Acad. Sci. U.S.A. 100 (22): 13013–8. doi:10.1073/pnas.2132646100. PMC 240736. PMID 14557543. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=240736.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
Schmutz J, Martin J, Terry A, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 5.". Nature 431 (7006): 268–74. doi:10.1038/nature02919. PMID 15372022.
Galli UM, Sauter M, Lecher B, et al. (2005). "Human endogenous retrovirus rec interferes with germ cell development in mice and may cause carcinoma in situ, the predecessor lesion of germ cell tumors.". Oncogene 24 (19): 3223–8. doi:10.1038/sj.onc.1208543. PMID 15735668.
Mayer J, Stuhr T, Reus K, et al. (2006). "Haplotype analysis of the human endogenous retrovirus locus HERV-K(HML-2.HOM) and its evolutionary implications.". J. Mol. Evol. 61 (5): 706–15. doi:10.1007/s00239-005-0066-7. PMID 16211423.
Romano CM, Ramalho RF, Zanotto PM (2006). "Tempo and mode of ERV-K evolution in human and chimpanzee genomes.". Arch. Virol. 151 (11): 2215–28. doi:10.1007/s00705-006-0792-1. PMID 16830071.

ERVK6

References

Further reading