EPS8L1

EPS8-like 1

PDB rendering based on 2cy4.

Available structures
PDB	2K2M, 2ROL

Identifiers

Symbols

EPS8L1; DRC3; EPS8R1; FLJ20258; MGC23164; MGC4642

External IDs

MGI: 1914675 HomoloGene: 15767 GeneCards: EPS8L1 Gene

Gene Ontology
Molecular function	• molecular_function
Cellular component	• cellular_component • cytoplasm
Biological process	• biological_process
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 19:
55.58 – 55.6 Mb

Chr 7:
4.41 – 4.43 Mb

PubMed search

[1]

[2]

Epidermal growth factor receptor kinase substrate 8-like protein 1 is an enzyme that in humans is encoded by the EPS8L1 gene.^[1]^[2]

This gene encodes a protein that is related to epidermal growth factor receptor pathway substrate 8 (EPS8), a substrate for the epidermal growth factor receptor. The function of this protein is unknown. Several alternatively spliced transcript variants encoding different isoforms exist.^[2]

References

^ Tocchetti A, Confalonieri S, Scita G, Di Fiore PP, Betsholtz C (Mar 2003). "In silico analysis of the EPS8 gene family: genomic organization, expression profile, and protein structure". Genomics 81 (2): 234–44. doi:10.1016/S0888-7543(03)00002-8. PMID 12620401.
^ ^a ^b "Entrez Gene: EPS8L1 EPS8-like 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54869.

Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129.
Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=524842.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Offenhäuser N, Borgonovo A, Disanza A, et al. (2004). "The eps8 Family of Proteins Links Growth Factor Stimulation to Actin Reorganization Generating Functional Redundancy in the Ras/Rac Pathway". Mol. Biol. Cell 15 (1): 91–8. doi:10.1091/mbc.E03-06-0427. PMC 307530. PMID 14565974. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=307530.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Wu K, Xu Z, Wang M, et al. (1999). "[Cloning and expression analyses of down-regulated cDNA C6-2A in human esophageal cancer]". Zhonghua Yi Xue Yi Chuan Xue Za Zhi 16 (5): 325–7. PMID 10514543.

PDB gallery

2cy4: Crystal structure of phosphotyrosine binding (PTB) domain of epidermal growth factor receptor pathway substrate-8 (EPS8) related protein 1 from Mus musculus (form-1 crystal)

2cy5: Crystal structure of phosphotyrosine binding (PTB) domain of epidermal growth factor receptor pathway substrate-8 (EPS8) related protein 1 from Mus musculus (form-2 crystal)

EPS8L1

References

Further reading