EPS15L1

Epidermal growth factor receptor pathway substrate 15-like 1

Identifiers

External IDs

MGI: 104582 HomoloGene: 31881 GeneCards: EPS15L1 Gene

Gene Ontology
Molecular function	• calcium ion binding
Cellular component	• nucleus • plasma membrane • plasma membrane • coated pit
Biological process	• endocytosis • epidermal growth factor receptor signaling pathway • negative regulation of epidermal growth factor receptor signaling pathway
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 19:
16.47 – 16.58 Mb

Chr 8:
74.86 – 74.95 Mb

PubMed search

[1]

[2]

Epidermal growth factor receptor substrate 15-like 1 is a protein that in humans is encoded by the EPS15L1 gene.^[1]

Interactions

EPS15L1 has been shown to interact with HRB.^[2]

References

^ "Entrez Gene: EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=58513.
^ Doria, M; Salcini A E, Colombo E, Parslow T G, Pelicci P G, Di Fiore P P (Dec. 1999). "The eps15 homology (EH) domain-based interaction between eps15 and hrb connects the molecular machinery of endocytosis to that of nucleocytosolic transport". J. Cell Biol. (UNITED STATES) 147 (7): 1379–84. doi:10.1083/jcb.147.7.1379. ISSN 0021-9525. PMC 2174238. PMID 10613896. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2174238.

Salcini AE, Confalonieri S, Doria M, et al. (1997). "Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module.". Genes Dev. 11 (17): 2239–49. doi:10.1101/gad.11.17.2239. PMC 275390. PMID 9303539. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=275390.
Carbone R, Fré S, Iannolo G, et al. (1998). "eps15 and eps15R are essential components of the endocytic pathway.". Cancer Res. 57 (24): 5498–504. PMID 9407958.
Coda L, Salcini AE, Confalonieri S, et al. (1998). "Eps15R is a tyrosine kinase substrate with characteristics of a docking protein possibly involved in coated pits-mediated internalization.". J. Biol. Chem. 273 (5): 3003–12. doi:10.1074/jbc.273.5.3003. PMID 9446614.
Chen H, Fre S, Slepnev VI, et al. (1998). "Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis.". Nature 394 (6695): 793–7. doi:10.1038/29555. PMID 9723620.
Ueki N, Oda T, Kondo M, et al. (1999). "Selection system for genes encoding nuclear-targeted proteins.". Nat. Biotechnol. 16 (13): 1338–42. doi:10.1038/4315. PMID 9853615.
Doria M, Salcini AE, Colombo E, et al. (2000). "The eps15 homology (EH) domain-based interaction between eps15 and hrb connects the molecular machinery of endocytosis to that of nucleocytosolic transport.". J. Cell Biol. 147 (7): 1379–84. doi:10.1083/jcb.147.7.1379. PMC 2174238. PMID 10613896. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2174238.
Offenhäuser N, Santolini E, Simeone A, Di Fiore PP (2000). "Differential patterns of expression of Eps15 and Eps15R during mouse embryogenesis.". Mech. Dev. 95 (1–2): 309–12. doi:10.1016/S0925-4773(00)00363-4. PMID 10906484.
Martina JA, Bonangelino CJ, Aguilar RC, Bonifacino JS (2001). "Stonin 2: an adaptor-like protein that interacts with components of the endocytic machinery". J. Cell Biol. 153 (5): 1111–20. doi:10.1083/jcb.153.5.1111. PMC 2174325. PMID 11381094. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2174325.
Poupon V, Polo S, Vecchi M, et al. (2002). "Differential nucleocytoplasmic trafficking between the related endocytic proteins Eps15 and Eps15R". J. Biol. Chem. 277 (11): 8941–8. doi:10.1074/jbc.M108385200. PMID 11777906.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=514446.
Schmid EM, Ford MG, Burtey A, et al. (2007). "Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly". PLoS Biol. 4 (9): e262. doi:10.1371/journal.pbio.0040262. PMC 1540706. PMID 16903783. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1540706.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

EPS15L1

Interactions

References

Further reading