EPH receptor B2

EPH receptor B2

PDB rendering based on 1b4f.
Identifiers
Symbols EPHB2; CAPB; DRT; EK5; EPHT3; ERK; Hek5; MGC87492; PCBC; Tyro5
External IDs OMIM: 600997 MGI: 99611 HomoloGene: 37925 GeneCards: EPHB2 Gene
EC number 2.7.10.1
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 2048 13844
Ensembl ENSG00000133216 ENSMUSG00000028664
UniProt P29323 Q6GTQ7
RefSeq (mRNA) NM_004442.6 NM_010142.2
RefSeq (protein) NP_004433.2 NP_034272.1
Location (UCSC) Chr 1:
23.04 – 23.24 Mb		 Chr 4:
136.2 – 136.39 Mb
PubMed search [1] [2]

Ephrin type-B receptor 2 is a protein that in humans is encoded by the EPHB2 gene.[1]

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.[2]

EphB2 is part of the NMDA signaling pathway.[3]

Interactions

EPH receptor B2 has been shown to interact with Src,[4][5] RAS p21 protein activator 1[5][6] and the Abl gene.[7]

References

  1. ^ Chan J, Watt VM (August 1991). "eek and erk, new members of the eph subclass of receptor protein-tyrosine kinases". Oncogene 6 (6): 1057–61. PMID 1648701. 
  2. ^ "Entrez Gene: EPHB2 EPH receptor B2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2048. 
  3. ^ "Protein provides Alzheimer's clue". 29 Nov 2010. http://www.nhs.uk/news/2010/11November/Pages/ephb2-protein-alzheimers-disease-reversal.aspx. 
  4. ^ Zisch, A H; Kalo M S, Chong L D, Pasquale E B (May 1998). "Complex formation between EphB2 and Src requires phosphorylation of tyrosine 611 in the EphB2 juxtamembrane region". Oncogene (ENGLAND) 16 (20): 2657–70. doi:10.1038/sj.onc.1201823. ISSN 0950-9232. PMID 9632142. 
  5. ^ a b Zisch, A H; Pazzagli C, Freeman A L, Schneller M, Hadman M, Smith J W, Ruoslahti E, Pasquale E B (January 2000). "Replacing two conserved tyrosines of the EphB2 receptor with glutamic acid prevents binding of SH2 domains without abrogating kinase activity and biological responses". Oncogene (ENGLAND) 19 (2): 177–87. doi:10.1038/sj.onc.1203304. ISSN 0950-9232. PMID 10644995. 
  6. ^ Holland, S J; Gale N W, Gish G D, Roth R A, Songyang Z, Cantley L C, Henkemeyer M, Yancopoulos G D, Pawson T (July 1997). "Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells". EMBO J. (ENGLAND) 16 (13): 3877–88. doi:10.1093/emboj/16.13.3877. ISSN 0261-4189. PMC 1170012. PMID 9233798. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1170012. 
  7. ^ Yu, H H; Zisch A H, Dodelet V C, Pasquale E B (July 2001). "Multiple signaling interactions of Abl and Arg kinases with the EphB2 receptor". Oncogene (England) 20 (30): 3995–4006. doi:10.1038/sj.onc.1204524. ISSN 0950-9232. PMID 11494128. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.