ELP3

Elongation protein 3 homolog (S. cerevisiae)

Identifiers

ELP3; FLJ10422; KAT9

External IDs

OMIM: 612722 MGI: 1921445 HomoloGene: 7105 GeneCards: ELP3 Gene

Gene Ontology
Molecular function	• DNA binding • histone acetyltransferase activity • protein binding • N-acetyltransferase activity • acyltransferase activity • phosphorylase kinase regulator activity • transferase activity • metal ion binding • iron-sulfur cluster binding
Cellular component	• nucleus • nucleolus • cytoplasm • transcription elongation factor complex • DNA-directed RNA polymerase II, holoenzyme
Biological process	• regulation of transcription from RNA polymerase II promoter • regulation of transcription from RNA polymerase II promoter
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000134014

ENSMUSG00000022031

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 8:
27.95 – 28.05 Mb

Chr 14:
66.15 – 66.21 Mb

PubMed search

Elongator complex protein 3 is a protein that in humans is encoded by the ELP3 gene.^[1]^[2]

References

^ Hawkes NA, Otero G, Winkler GS, Marshall N, Dahmus ME, Krappmann D, Scheidereit C, Thomas CL, Schiavo G, Erdjument-Bromage H, Tempst P, Svejstrup JQ (Jan 2002). "Purification and characterization of the human elongator complex". J Biol Chem 277 (4): 3047–52. doi:10.1074/jbc.M110445200. PMID 11714725.
^ "Entrez Gene: ELP3 elongation protein 3 homolog (S. cerevisiae)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55140.

Further reading

Rengo F, Brevetti G, Piscione F, et al. (1977). "[Behavior of some metabolic parameters during post-ischemic and post-contraction vasodilation in normal subjects]". Bollettino della Società italiana di cardiologia 20 (12): 1801–6. PMID 10936.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Ninomiya Y, Okada M, Kotomura N, et al. (1996). "Genomic organization and isoforms of the mouse ELP gene.". J. Biochem. 118 (2): 380–9. PMID 8543574.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310948.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=311072.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1083732.
Kim JH, Lane WS, Reinberg D (2002). "Human Elongator facilitates RNA polymerase II transcription through chromatin.". Proc. Natl. Acad. Sci. U.S.A. 99 (3): 1241–6. doi:10.1073/pnas.251672198. PMC 122174. PMID 11818576. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=122174.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528930.
Kouskouti A, Talianidis I (2005). "Histone modifications defining active genes persist after transcriptional and mitotic inactivation.". EMBO J. 24 (2): 347–57. doi:10.1038/sj.emboj.7600516. PMC 545808. PMID 15616580. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=545808.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1347501.
Han Q, Hou X, Su D, et al. (2007). "hELP3 subunit of the Elongator complex regulates the transcription of HSP70 gene in human cells.". Acta Biochim. Biophys. Sin. (Shanghai) 39 (6): 453–61. doi:10.1111/j.1745-7270.2007.00293.x. PMID 17558451.