EIF5A2

Eukaryotic translation initiation factor 5A2

Identifiers

EIF5A2; EIF-5A2; eIF5AII

External IDs

OMIM: 605782 MGI: 1933735 HomoloGene: 1490 GeneCards: EIF5A2 Gene

Gene Ontology
Molecular function	• RNA binding • translation elongation factor activity • protein binding • ribosome binding
Cellular component	• nucleus • nuclear pore • cytoplasm • endoplasmic reticulum • endoplasmic reticulum membrane • cytosol • cytosol • membrane
Biological process	• translational frameshifting • spermatogenesis • positive regulation of cell proliferation • peptidyl-lysine modification to hypusine • polyamine homeostasis • protein transport • post-translational protein modification • cellular protein metabolic process • positive regulation of translational elongation • positive regulation of translational termination • mRNA transport • transmembrane transport
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 3:
170.61 – 170.63 Mb

Chr 3:
28.68 – 28.7 Mb

PubMed search

[1]

[2]

Eukaryotic translation initiation factor 5A-2 is a protein that in humans is encoded by the EIF5A2 gene.^[1]

References

^ "Entrez Gene: EIF5A2 eukaryotic translation initiation factor 5A2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56648.

Jenkins ZA, Hååg PG, Johansson HE (2001). "Human eIF5A2 on chromosome 3q25-q27 is a phylogenetically conserved vertebrate variant of eukaryotic translation initiation factor 5A with tissue-specific expression.". Genomics 71 (1): 101–9. doi:10.1006/geno.2000.6418. PMID 11161802.
Guan XY, Sham JS, Tang TC, et al. (2001). "Isolation of a novel candidate oncogene within a frequently amplified region at 3q26 in ovarian cancer.". Cancer Res. 61 (9): 3806–9. PMID 11325856.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Clement PM, Henderson CA, Jenkins ZA, Smit-McBride Z, Wolff EC, Hershey JW, Park MH, Johansson HE. (2003). "Identification and characterization of eukaryotic initiation factor 5A-2.". Eur. J. Biochem. 270 (21): 4254–63. doi:10.1046/j.1432-1033.2003.03806.x. PMID 14622290.
Guan XY, Fung JM, Ma NF, et al. (2004). "Oncogenic role of eIF-5A2 in the development of ovarian cancer.". Cancer Res. 64 (12): 4197–200. doi:10.1158/0008-5472.CAN-03-3747. PMID 15205331.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Christensen GL, Ivanov IP, Atkins JF, et al. (2005). "Screening the SPO11 and EIF5A2 genes in a population of infertile men.". Fertil. Steril. 84 (3): 758–60. doi:10.1016/j.fertnstert.2005.03.053. PMID 16169419.
Clement PM, Johansson HE, Wolff EC, Park MH (2006). "Differential expression of eIF5A-1 and eIF5A-2 in human cancer cells.". FEBS J. 273 (6): 1102–14. doi:10.1111/j.1742-4658.2006.05135.x. PMID 16519677.
Xie D, Ma NF, Pan ZZ, Wu HX, Liu YD, Wu GQ, Kung HF, Guan XY (2008). "Overexpression of EIF-5A2 is associated with metastasis of human colorectal carcinoma.". Hum Pathol. 39 (1): 8–6. doi:10.1016/j.humpath.2007.05.011. PMID 17949776.
Yang GF, Xie D, Liu JH, Luo JH, Li LJ, Hua WF, Wu HM, Kung HF, Zeng YX, Guan XY (2009). "Expression and amplification of eIF-5A2 in human epithelial ovarian tumors and overexpression of EIF-5A2 is a new independent predictor of outcome in patients with ovarian carcinoma.". Gynecol Oncol. 112 (2): 314–8. doi:10.1016/j.ygyno.2008.10.024. PMID 19054548.
Chen W, Luo JH, Hua WF, Zhou FJ, Lin MC, Kung HF, Zeng YX, Guan XY, Xie D (2009). "Overexpression of EIF-5A2 is an independent predictor of outcome in patients of urothelial carcinoma of the bladder treated with radical cystectomy.". Cancer Epidemiol Biomarkers Prev. 12 (2): 400-8. doi:10.1158/1055-9965.EPI-08-0754. PMID 19155439.
Luo JH, Hua WF, Rao HL, Liao YJ, Kung HF, Zeng YX, Guan XY, Chen W, Xie D (2009). "Overexpression of EIF-5A2 predicts tumor recurrence and progression in pTa/pT1 urothelial carcinoma of the bladder.". Cancer Sci. 100 (5): 896-902. doi:10.1111/j.1349-7006.2009.01126.x. PMID 19298601.
Tang DJ, Dong SS, Ma NF, Xie D, Chen L, Fu L, Lau SH, Li Y, Li Y, Guan XY (2010). "Overexpression of eukaryotic initiation factor 5A2 enhances cell motility and promotes tumor metastasis in hepatocellular carcinoma.". Hepatology. 51 (4): 1255-63. doi:10.1002/hep.23451. PMID 20112425.
Chen M, Huang JD, Deng HK, Dong S, Deng W, Tsang SL, Huen MS, Chen L, Zan T, Zhu GX, Guan XY (2011). "Overexpression of eIF-5A2 in mice causes accelerated organismal aging by increasing chromosome instability.". BMC Cancer. 11: 199. doi:10.1186/1471-2407-11-199. PMID 21612665.
He LR, Zhao HY, Li BK, Liu YH, Liu MZ, Guan XY, Bian XW, Zeng YX, Xie D (2011). "Overexpression of eIF5A-2 is an adverse prognostic marker of survival in stage I non-small cell lung cancer patients.". Int J Cancer. 129 (1): 143–50. doi:10.1002/ijc.25669. PMID 20830705.

Protein biosynthesis: translation (prokaryotic, eukaryotic)

Ribosomal proteins

Initiation factor

Prokaryotic	PIF-1 · PIF-2 · PIF-3

Archaeal	aIF1 · aIF2 · aIF5 · aIF6

Eukaryotic	eIF1 (EIF1AX, AY, 1B) eIF2 (EIF2S1, EIF2S2, EIF2S3) · EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5 · EIF-2 kinase eIF3 (EIF3A, B, C, D, F, G, H, I, J, K, M, S6) eIF4 (EIF4A2, A3, B, E1, E2, G1, G2, G3, H) eIF5 (EIF5A, A2, B) eIF6 (EIF6)

Elongation factor

Prokaryotic	EF-Tu, EF-Ts, EF-G

Archaeal	aEF-1, aEF-2

Eukaryotic	EEF-1 (EEF1A1, EEF1A2, EEF1A3, EEF1B1, EEF1B2, EEF1B3, EEF1B4, EEF1D, EEF1E1, EEF1G) · EEF2

Release factor

Prokaryotic · Archaeal · Eukaryotic (ETF1)

Other

RPS1 · RPS2 · RPS3 · RPS4 · RPS5 · RPS6 · RPS7 · RPS8 · RPS9 · RPS10 · RPS11 · RPS12 · RPS13 · RPS14 · RPS15 · RPS16 · RPS17 · RPS18 · RPS19 · RPS20 · RPS21 · RPS22 · RPS23 · RPS24 · RPS25 · RPS26 · RPS27 · RPS28 · RPS29

Other concepts

Aminoacyl tRNA synthetase · Reading frame · Start codon · Stop codon · Shine-Dalgarno sequence/Kozak consensus sequence

see also disorders of translation and posttranslational modification
B bsyn: dna (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°)

EIF5A2

References

Further reading