EIF3S6

Eukaryotic translation initiation factor 3, subunit E

Identifiers

EIF3E; EIF3-P48; EIF3S6; INT6; eIF3-p46

External IDs

OMIM: 602210 MGI: 99257 HomoloGene: 1205 GeneCards: EIF3E Gene

Gene Ontology
Molecular function	• translation initiation factor activity • translation initiation factor activity • translation initiation factor activity • protein binding • protein N-terminus binding
Cellular component	• chromatin • nucleus • nucleoplasm • cytoplasm • cytosol • cytosol • eukaryotic translation initiation factor 3 complex • eukaryotic translation initiation factor 3 complex • PML body
Biological process	• nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • translation • translational initiation • translational initiation • regulation of translational initiation • gene expression • cellular protein metabolic process • negative regulation of translational initiation
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 8:
109.21 – 109.45 Mb

Chr 15:
43.08 – 43.11 Mb

PubMed search

[1]

[2]

Eukaryotic translation initiation factor 3 subunit E is a protein that in humans is encoded by the EIF3E gene.^[1]^[2]^[3]

Interactions

EIF3S6 has been shown to interact with TRIM27,^[4] EIF3A,^[5]^[6]^[7] BAT2,^[8] COPS6^[9] and CSN3.^[9]

References

^ Miyazaki S, Imatani A, Ballard L, Marchetti A, Buttitta F, Albertsen H, Nevanlinna HA, Gallahan D, Callahan R (January 1998). "The chromosome location of the human homolog of the mouse mammary tumor-associated gene INT6 and its status in human breast carcinomas". Genomics 46 (1): 155–8. doi:10.1006/geno.1997.4996. PMID 9403073.
^ Asano K, Merrick WC, Hershey JW (October 1997). "The translation initiation factor eIF3-p48 subunit is encoded by int-6, a site of frequent integration by the mouse mammary tumor virus genome". J Biol Chem 272 (38): 23477–80. doi:10.1074/jbc.272.38.23477. PMID 9295280.
^ "Entrez Gene: EIF3S6 Eukaryotic translation initiation factor 3, subunit 6 48kDa". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3646.
^ Morris-Desbois, C; Bochard V, Reynaud C, Jalinot P (October 1999). "Interaction between the Ret finger protein and the Int-6 gene product and co-localisation into nuclear bodies". J. Cell. Sci. (ENGLAND) 112 ( Pt 19): 3331–42. ISSN 0021-9533. PMID 10504338.
^ Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948.
^ Mayeur, Greg L; Fraser Christopher S, Peiretti Franck, Block Karen L, Hershey John W B (October 2003). "Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3". Eur. J. Biochem. (Germany) 270 (20): 4133–9. doi:10.1046/j.1432-1033.2003.03807.x. ISSN 0014-2956. PMID 14519125.
^ Morris-Desbois, C; Réty S, Ferro M, Garin J, Jalinot P (December 2001). "The human protein HSPC021 interacts with Int-6 and is associated with eukaryotic translation initiation factor 3". J. Biol. Chem. (United States) 276 (49): 45988–95. doi:10.1074/jbc.M104966200. ISSN 0021-9258. PMID 11590142.
^ Lehner, Ben; Semple Jennifer I, Brown Stephanie E, Counsell Damian, Campbell R Duncan, Sanderson Christopher M (January 2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics (United States) 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. ISSN 0888-7543. PMID 14667819.
^ ^a ^b Hoareau Alves, Karine; Bochard Valérie, Réty Stéphane, Jalinot Pierre (September 2002). "Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome". FEBS Lett. (Netherlands) 527 (1–3): 15–21. doi:10.1016/S0014-5793(02)03147-2. ISSN 0014-5793. PMID 12220626.

Marchetti A, Buttitta F, Miyazaki S, Gallahan D, Smith GH, Callahan R (1995). "Int-6, a highly conserved, widely expressed gene, is mutated by mouse mammary tumor virus in mammary preneoplasia". J Virol. 69 (3): 1932–8.. PMC 188811. PMID 7853537. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=188811.
Desbois C, Rousset R, Bantignies F, Jalinot P (1996). "Exclusion of Int-6 from PML nuclear bodies by binding to the HTLV–I Tax oncoprotein". Science 273 (5277): 951–3. doi:10.1126/science.273.5277.951. PMID 8688078.
Asano K, Kinzy TG, Merrick WC, Hershey JW (1997). "Conservation and diversity of eukaryotic translation initiation factor eIF3". J. Biol. Chem. 272 (2): 1101–9. doi:10.1074/jbc.272.2.1101. PMID 8995409.
Méthot N, Rom E, Olsen H, Sonenberg N (1997). "The human homologue of the yeast Prt1 protein is an integral part of the eukaryotic initiation factor 3 complex and interacts with p170". J. Biol. Chem. 272 (2): 1110–6. doi:10.1074/jbc.272.2.1110. PMID 8995410.
Block KL, Vornlocher HP, Hershey JW (1998). "Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3". J. Biol. Chem. 273 (48): 31901–8. doi:10.1074/jbc.273.48.31901. PMID 9822659.
Morris-Desbois C, Bochard V, Reynaud C, Jalinot P (1999). "Interaction between the Ret finger protein and the Int-6 gene product and co-localisation into nuclear bodies". J. Cell. Sci. 112 ( Pt 19): 3331–42. PMID 10504338.
Guo J, Sen GC (2000). "Characterization of the Interaction between the Interferon-Induced Protein P56 and the Int6 Protein Encoded by a Locus of Insertion of the Mouse Mammary Tumor Virus". J. Virol. 74 (4): 1892–9. doi:10.1128/JVI.74.4.1892-1899.2000. PMC 111667. PMID 10644362. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=111667.
Guo J, Hui DJ, Merrick WC, Sen GC (2001). "A new pathway of translational regulation mediated by eukaryotic initiation factor 3". EMBO J. 19 (24): 6891–9. doi:10.1093/emboj/19.24.6891. PMC 305884. PMID 11118224. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=305884.
Yen HC, Chang EC (2001). "Yin6, a fission yeast Int6 homolog, complexes with Moe1 and plays a role in chromosome segregation". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14370–5. doi:10.1073/pnas.97.26.14370. PMC 18925. PMID 11121040. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=18925.
Morris-Desbois C, Réty S, Ferro M et al. (2002). "The human protein HSPC021 interacts with Int-6 and is associated with eukaryotic translation initiation factor 3". J. Biol. Chem. 276 (49): 45988–95. doi:10.1074/jbc.M104966200. PMID 11590142.
Hoareau Alves K, Bochard V, Réty S, Jalinot P (2002). "Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome". FEBS Lett. 527 (1–3): 15–21. doi:10.1016/S0014-5793(02)03147-2. PMID 12220626.
Neuveut C, Jin DY, Semmes OJ et al. (1997). "Divergent Subcellular Locations of HTLV–I Tax and Int-6: A Contrast between in vitro Protein-Protein Binding and Intracellular Protein Colocalization". Journal of biomedical science 4 (5): 229–234. doi:10.1007/BF02253422. PMID 12386384.
Huang GJ, Zhang ZQ, Jin DY (2002). "Stimulation of IKK-gamma oligomerization by the human T-cell leukemia virus oncoprotein Tax". FEBS Lett. 531 (3): 494–8. doi:10.1016/S0014-5793(02)03590-1. PMID 12435599.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Yen HC, Gordon C, Chang EC (2003). "Schizosaccharomyces pombe Int6 and Ras homologs regulate cell division and mitotic fidelity via the proteasome". Cell 112 (2): 207–17. doi:10.1016/S0092-8674(03)00043-6. PMID 12553909.
Mayeur GL, Fraser CS, Peiretti F et al. (2003). "Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3". Eur. J. Biochem. 270 (20): 4133–9. doi:10.1046/j.1432-1033.2003.03807.x. PMID 14519125.
Lehner B, Semple JI, Brown SE et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Watkins SJ, Norbury CJ (2004). "Cell cycle-related variation in subcellular localization of eIF3e/INT6 in human fibroblasts". Cell Prolif. 37 (2): 149–60. doi:10.1111/j.1365-2184.2004.00305.x. PMID 15030549.

Protein biosynthesis: translation (prokaryotic, eukaryotic)

Ribosomal proteins

Initiation factor

Prokaryotic	PIF-1 · PIF-2 · PIF-3

Archaeal	aIF1 · aIF2 · aIF5 · aIF6

Eukaryotic	eIF1 (EIF1AX, AY, 1B) eIF2 (EIF2S1, EIF2S2, EIF2S3) · EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5 · EIF-2 kinase eIF3 (EIF3A, B, C, D, F, G, H, I, J, K, M, S6) eIF4 (EIF4A2, A3, B, E1, E2, G1, G2, G3, H) eIF5 (EIF5A, A2, B) eIF6 (EIF6)

Elongation factor

Prokaryotic	EF-Tu, EF-Ts, EF-G

Archaeal	aEF-1, aEF-2

Eukaryotic	EEF-1 (EEF1A1, EEF1A2, EEF1A3, EEF1B1, EEF1B2, EEF1B3, EEF1B4, EEF1D, EEF1E1, EEF1G) · EEF2

Release factor

Prokaryotic · Archaeal · Eukaryotic (ETF1)

Other

RPS1 · RPS2 · RPS3 · RPS4 · RPS5 · RPS6 · RPS7 · RPS8 · RPS9 · RPS10 · RPS11 · RPS12 · RPS13 · RPS14 · RPS15 · RPS16 · RPS17 · RPS18 · RPS19 · RPS20 · RPS21 · RPS22 · RPS23 · RPS24 · RPS25 · RPS26 · RPS27 · RPS28 · RPS29

Other concepts

Aminoacyl tRNA synthetase · Reading frame · Start codon · Stop codon · Shine-Dalgarno sequence/Kozak consensus sequence

see also disorders of translation and posttranslational modification
B bsyn: dna (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°)

EIF3S6

Interactions

References

Further reading