EIF2B4

Eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa

Identifiers

EIF2B4; DKFZp586J0119; EIF-2B; EIF2B; EIF2Bdelta

External IDs

OMIM: 606687 MGI: 95300 HomoloGene: 5976 GeneCards: EIF2B4 Gene

Gene Ontology
Molecular function	• translation initiation factor activity • guanyl-nucleotide exchange factor activity • guanyl-nucleotide exchange factor activity • protein binding • translation initiation factor binding
Cellular component	• cytoplasm • cytosol • eukaryotic translation initiation factor 2B complex
Biological process	• ovarian follicle development • translation • translational initiation • regulation of translation • response to heat • response to heat • response to glucose stimulus • gene expression • oligodendrocyte development • negative regulation of translational initiation in response to stress • myelination • response to peptide hormone stimulus • cellular metabolic process • cellular protein metabolic process • negative regulation of translational initiation • cellular response to stimulus
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 2:
27.59 – 27.59 Mb

Chr 5:
31.49 – 31.5 Mb

PubMed search

[1]

[2]

Translation initiation factor eIF-2B subunit delta is a protein that in humans is encoded by the EIF2B4 gene.^[1]^[2]^[3]

References

^ Price NT, Mellor H, Craddock BL, Flowers KM, Kimball SR, Wilmer T, Jefferson LS, Proud CG (Nov 1996). "eIF2B, the guanine nucleotide-exchange factor for eukaryotic initiation factor 2. Sequence conservation between the alpha, beta and delta subunits of eIF2B from mammals and yeast". Biochem J 318 ( Pt 2): 637–43. PMC 1217679. PMID 8929216. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1217679.
^ Henderson RA, Krissansen GW, Yong RY, Leung E, Watson JD, Dholakia JN (Dec 1994). "The delta-subunit of murine guanine nucleotide exchange factor eIF-2B. Characterization of cDNAs predicts isoforms differing at the amino-terminal end". J Biol Chem 269 (48): 30517–23. PMID 7982969.
^ "Entrez Gene: EIF2B4 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8890.

Welsh GI, Miyamoto S, Price NT, et al. (1996). "T-cell activation leads to rapid stimulation of translation initiation factor eIF2B and inactivation of glycogen synthase kinase-3.". J. Biol. Chem. 271 (19): 11410–3. doi:10.1074/jbc.271.19.11410. PMID 8626696.
Yang W, Hinnebusch AG (1996). "Identification of a regulatory subcomplex in the guanine nucleotide exchange factor eIF2B that mediates inhibition by phosphorylated eIF2.". Mol. Cell. Biol. 16 (11): 6603–16. PMC 231662. PMID 8887689. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=231662.
Kimball SR, Heinzinger NK, Horetsky RL, Jefferson LS (1998). "Identification of interprotein interactions between the subunits of eukaryotic initiation factors eIF2 and eIF2B.". J. Biol. Chem. 273 (5): 3039–44. doi:10.1074/jbc.273.5.3039. PMID 9446619.
Gomez E, Pavitt GD (2000). "Identification of domains and residues within the epsilon subunit of eukaryotic translation initiation factor 2B (eIF2Bepsilon) required for guanine nucleotide exchange reveals a novel activation function promoted by eIF2B complex formation.". Mol. Cell. Biol. 20 (11): 3965–76. doi:10.1128/MCB.20.11.3965-3976.2000. PMC 85753. PMID 10805739. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=85753.
Anthony TG, Fabian JR, Kimball SR, Jefferson LS (2000). "Identification of domains within the epsilon-subunit of the translation initiation factor eIF2B that are necessary for guanine nucleotide exchange activity and eIF2B holoprotein formation.". Biochim. Biophys. Acta 1492 (1): 56–62. PMID 10858531.
Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=16901.
Williams DD, Price NT, Loughlin AJ, Proud CG (2001). "Characterization of the mammalian initiation factor eIF2B complex as a GDP dissociation stimulator protein.". J. Biol. Chem. 276 (27): 24697–703. doi:10.1074/jbc.M011788200. PMID 11323413.
van der Knaap MS, Leegwater PA, Könst AA, et al. (2002). "Mutations in each of the five subunits of translation initiation factor eIF2B can cause leukoencephalopathy with vanishing white matter.". Ann. Neurol. 51 (2): 264–70. doi:10.1002/ana.10112. PMID 11835386.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Fogli A, Dionisi-Vici C, Deodato F, et al. (2003). "A severe variant of childhood ataxia with central hypomyelination/vanishing white matter leukoencephalopathy related to EIF21B5 mutation.". Neurology 59 (12): 1966–8. PMID 12499492.
Kobayashi H, Børsheim E, Anthony TG, et al. (2003). "Reduced amino acid availability inhibits muscle protein synthesis and decreases activity of initiation factor eIF2B.". Am. J. Physiol. Endocrinol. Metab. 284 (3): E488–98. doi:10.1152/ajpendo.00094.2002. PMID 12556349.
Fogli A, Rodriguez D, Eymard-Pierre E, et al. (2003). "Ovarian failure related to eukaryotic initiation factor 2B mutations.". Am. J. Hum. Genet. 72 (6): 1544–50. doi:10.1086/375404. PMC 1180314. PMID 12707859. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1180314.
van der Knaap MS, van Berkel CG, Herms J, et al. (2004). "eIF2B-related disorders: antenatal onset and involvement of multiple organs.". Am. J. Hum. Genet. 73 (5): 1199–207. doi:10.1086/379524. PMC 1180499. PMID 14566705. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1180499.
Fogli A, Schiffmann R, Hugendubler L, et al. (2005). "Decreased guanine nucleotide exchange factor activity in eIF2B-mutated patients.". Eur. J. Hum. Genet. 12 (7): 561–6. doi:10.1038/sj.ejhg.5201189. PMID 15054402.
Li W, Wang X, Van Der Knaap MS, Proud CG (2004). "Mutations linked to leukoencephalopathy with vanishing white matter impair the function of the eukaryotic initiation factor 2B complex in diverse ways.". Mol. Cell. Biol. 24 (8): 3295–306. doi:10.1128/MCB.24.8.3295-3306.2004. PMC 381664. PMID 15060152. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=381664.
Van Haren K, van der Voorn JP, Peterson DR, et al. (2004). "The life and death of oligodendrocytes in vanishing white matter disease.". J. Neuropathol. Exp. Neurol. 63 (6): 618–30. PMID 15217090.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Fogli A, Gauthier-Barichard F, Schiffmann R, et al. (2004). "Screening for known mutations in EIF2B genes in a large panel of patients with premature ovarian failure.". BMC women's health [electronic resource]. 4: 8. doi:10.1186/1472-6874-4-8. PMC 529454. PMID 15507143. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=529454.

Protein biosynthesis: translation (prokaryotic, eukaryotic)

Ribosomal proteins

Initiation factor

Prokaryotic	PIF-1 · PIF-2 · PIF-3

Archaeal	aIF1 · aIF2 · aIF5 · aIF6

Eukaryotic	eIF1 (EIF1AX, AY, 1B) eIF2 (EIF2S1, EIF2S2, EIF2S3) · EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5 · EIF-2 kinase eIF3 (EIF3A, B, C, D, F, G, H, I, J, K, M, S6) eIF4 (EIF4A2, A3, B, E1, E2, G1, G2, G3, H) eIF5 (EIF5A, A2, B) eIF6 (EIF6)

Elongation factor

Prokaryotic	EF-Tu, EF-Ts, EF-G

Archaeal	aEF-1, aEF-2

Eukaryotic	EEF-1 (EEF1A1, EEF1A2, EEF1A3, EEF1B1, EEF1B2, EEF1B3, EEF1B4, EEF1D, EEF1E1, EEF1G) · EEF2

Release factor

Prokaryotic · Archaeal · Eukaryotic (ETF1)

Other

RPS1 · RPS2 · RPS3 · RPS4 · RPS5 · RPS6 · RPS7 · RPS8 · RPS9 · RPS10 · RPS11 · RPS12 · RPS13 · RPS14 · RPS15 · RPS16 · RPS17 · RPS18 · RPS19 · RPS20 · RPS21 · RPS22 · RPS23 · RPS24 · RPS25 · RPS26 · RPS27 · RPS28 · RPS29

Other concepts

Aminoacyl tRNA synthetase · Reading frame · Start codon · Stop codon · Shine-Dalgarno sequence/Kozak consensus sequence

see also disorders of translation and posttranslational modification
B bsyn: dna (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°)

EIF2B4

References

Further reading