EIF2A

Eukaryotic translation initiation factor 2A, 65kDa

Identifiers

EIF2A; EIF-2A; MST089; MSTP004; MSTP089

External IDs

OMIM: 609234 MGI: 1098684 HomoloGene: 5969 GeneCards: EIF2A Gene

Gene Ontology
Molecular function	• tRNA binding • translation initiation factor activity • ribosome binding
Cellular component	• cytoplasm • eukaryotic translation initiation factor 2 complex
Biological process	• translational initiation • regulation of translation • protein phosphorylation • positive regulation of signal transduction • SREBP-mediated signaling pathway • ribosome assembly
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000144895

ENSMUSG00000027810

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 3:
150.26 – 150.3 Mb

Chr 3:
58.33 – 58.36 Mb

PubMed search

Eukaryotic translation initiation factor 2A is a protein that in humans is encoded by the EIF2A gene.^[1]^[2]^[3]

EIF2A is a 65-kD protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes (Zoll et al., 2002).[supplied by OMIM]^[3]

See also

eIF2

References

^ Zoll WL, Horton LE, Komar AA, Hensold JO, Merrick WC (Sep 2002). "Characterization of mammalian eIF2A and identification of the yeast homolog". J Biol Chem 277 (40): 37079–87. doi:10.1074/jbc.M207109200. PMID 12133843.
^ Merrick WC (Aug 1992). "Mechanism and regulation of eukaryotic protein synthesis". Microbiol Rev 56 (2): 291–315. PMC 372869. PMID 1620067. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=372869.
^ ^a ^b "Entrez Gene: EIF2A eukaryotic translation initiation factor 2A, 65kDa". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83939.

Further reading

Koumenis C, Naczki C, Koritzinsky M, et al. (2002). "Regulation of Protein Synthesis by Hypoxia via Activation of the Endoplasmic Reticulum Kinase PERK and Phosphorylation of the Translation Initiation Factor eIF2α". Mol. Cell. Biol. 22 (21): 7405–16. doi:10.1128/MCB.22.21.7405-7416.2002. PMC 135664. PMID 12370288. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=135664.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Page AB, Owen CR, Kumar R, et al. (2003). "Persistent eIF2alpha(P) is colocalized with cytoplasmic cytochrome c in vulnerable hippocampal neurons after 4 hours of reperfusion following 10-minute complete brain ischemia". Acta Neuropathol. 106 (1): 8–16. doi:10.1007/s00401-003-0693-2. PMID 12687390.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Ito T, Marintchev A, Wagner G (2005). "Solution structure of human initiation factor eIF2alpha reveals homology to the elongation factor eEF1B". Structure 12 (9): 1693–704. doi:10.1016/j.str.2004.07.010. PMID 15341733.
Weiser DC, Sikes S, Li S, Shenolikar S (2005). "The inhibitor-1 C terminus facilitates hormonal regulation of cellular protein phosphatase-1: functional implications for inhibitor-1 isoforms". J. Biol. Chem. 279 (47): 48904–14. doi:10.1074/jbc.M404416200. PMID 15345721.
Komar AA, Gross SR, Barth-Baus D, et al. (2005). "Novel characteristics of the biological properties of the yeast Saccharomyces cerevisiae eukaryotic initiation factor 2A". J. Biol. Chem. 280 (16): 15601–11. doi:10.1074/jbc.M413728200. PMID 15718232.
Wang J, Laschinger C, Zhao XH, et al. (2005). "Mechanical force activates eIF-2alpha phospho-kinases in fibroblast". Biochem. Biophys. Res. Commun. 330 (1): 123–30. doi:10.1016/j.bbrc.2005.02.140. PMID 15781241.
Gorrini C, Loreni F, Gandin V, et al. (2005). "Fibronectin controls cap-dependent translation through β1 integrin and eukaryotic initiation factors 4 and 2 coordinated pathways". Proc. Natl. Acad. Sci. U.S.A. 102 (26): 9200–5. doi:10.1073/pnas.0409513102. PMC 1166589. PMID 15961545. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1166589.
Su Q, Wang S, Baltzis D, et al. (2006). "Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2α RNA-dependent protein kinase". Proc. Natl. Acad. Sci. U.S.A. 103 (1): 63–8. doi:10.1073/pnas.0508207103. PMC 1324992. PMID 16373505. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1324992.
Squatrito M, Mancino M, Sala L, Draetta GF (2006). "Ebp1 is a dsRNA-binding protein associated with ribosomes that modulates eIF2alpha phosphorylation". Biochem. Biophys. Res. Commun. 344 (3): 859–68. doi:10.1016/j.bbrc.2006.03.205. PMID 16631606.
Scheuner D, Patel R, Wang F, et al. (2006). "Double-stranded RNA-dependent protein kinase phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 mediates apoptosis". J. Biol. Chem. 281 (30): 21458–68. doi:10.1074/jbc.M603784200. PMID 16717090.
Mazroui R, Sukarieh R, Bordeleau ME, et al. (2007). "Inhibition of Ribosome Recruitment Induces Stress Granule Formation Independently of Eukaryotic Initiation Factor 2α Phosphorylation". Mol. Biol. Cell 17 (10): 4212–9. doi:10.1091/mbc.E06-04-0318. PMC 1635342. PMID 16870703. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1635342.
Fribley AM, Evenchik B, Zeng Q, et al. (2006). "Proteasome inhibitor PS-341 induces apoptosis in cisplatin-resistant squamous cell carcinoma cells by induction of Noxa". J. Biol. Chem. 281 (42): 31440–7. doi:10.1074/jbc.M604356200. PMID 16928686.
Fritsch RM, Schneider G, Saur D, et al. (2007). "Translational repression of MCL-1 couples stress-induced eIF2 alpha phosphorylation to mitochondrial apoptosis initiation". J. Biol. Chem. 282 (31): 22551–62. doi:10.1074/jbc.M702673200. PMID 17553788.
Nayak R, Pintel DJ (2007). "Adeno-Associated Viruses Can Induce Phosphorylation of eIF2α via PKR Activation, Which Can Be Overcome by Helper Adenovirus Type 5 Virus-Associated RNA". J. Virol. 81 (21): 11908–16. doi:10.1128/JVI.01132-07. PMC 2168773. PMID 17715234. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2168773.