LPAR1

Lysophosphatidic acid receptor 1
Identifiers
Symbols LPAR1; EDG2; GPR26; Gpcr26; LPA1; Mrec1.3; VZG1; edg-2; rec.1.3; vzg-1
External IDs OMIM602282 MGI108429 HomoloGene1072 IUPHAR: LPA1 GeneCards: LPAR1 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 1902 14745
Ensembl ENSG00000198121 ENSMUSG00000038668
UniProt Q92633 Q544V2
RefSeq (mRNA) NM_001401.3 NM_010336
RefSeq (protein) NP_001392.2 NP_034466
Location (UCSC) Chr 9:
113.64 – 113.8 Mb
Chr 4:
58.45 – 58.57 Mb
PubMed search [1] [2]

Lysophosphatidic acid receptor 1 also known as LPA1 is a protein that in humans is encoded by the LPAR1 gene.[1][2][3] LPA1 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).[4]

Contents

Function

The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Alternative splicing of this gene has been observed and two transcript variants have been described, each encoding identical proteins. An alternate translation start codon has been identified, which results in isoforms differing in the N-terminal extracellular tail. In addition, an alternate polyadenylation site has been reported.[1]

See also

References

  1. ^ a b "Entrez Gene: LPAR1 Lysophosphatidic acid receptor 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1902. 
  2. ^ Hecht JH, Weiner JA, Post SR, Chun J (November 1996). "Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex". J. Cell Biol. 135 (4): 1071–83. doi:10.1083/jcb.135.4.1071. PMC 2133395. PMID 8922387. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2133395. 
  3. ^ An S, Dickens MA, Bleu T, Hallmark OG, Goetzl EJ (February 1997). "Molecular cloning of the human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid". Biochem. Biophys. Res. Commun. 231 (3): 619–22. doi:10.1006/bbrc.1997.6150. PMID 9070858. 
  4. ^ Choi JW, Herr DR, Noguchi K, Yung YC, Lee C-W, Mutoh T, Lin M-E, Teo ST, Park KE, Mosley AN, Chun J (January 2010). "LPA Receptors: Subtypes and Biological Actions". Annual Review of Pharmacology and Toxicology 50 (1): 157–186. doi:10.1146/annurev.pharmtox.010909.105753. PMID 20055701. http://arjournals.annualreviews.org/doi/abs/10.1146/annurev.pharmtox.010909.105753. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.