EDF1
Endothelial differentiation-related factor 1 is a protein that in humans is encoded by the EDF1 gene.[1][2][3]
This gene encodes a protein that may regulate endothelial cell differentiation. It has been postulated that the protein functions as a bridging molecule that interconnects regulatory proteins and the basal transcriptional machinery, thereby modulating the transcription of genes involved in endothelial differentiation. This protein has also been found to act as a transcriptional coactivator by interconnecting the general transcription factor TATA element-binding protein (TBP) and gene-specific activators. Two alternatively spliced transcripts which encode distinct proteins have been found for this gene.[3]
Interactions
EDF1 has been shown to interact with Peroxisome proliferator-activated receptor gamma,[4] TATA binding protein[4][5][6] and Liver X receptor alpha.[4]
References
- ^ Dragoni I, Mariotti M, Consalez GG, Soria MR, Maier JA (Dec 1998). "EDF-1, a novel gene product down-regulated in human endothelial cell differentiation". J Biol Chem 273 (47): 31119–24. doi:10.1074/jbc.273.47.31119. PMID 9813014.
- ^ Ballabio E, Mariotti M, De Benedictis L, Maier JA (Apr 2004). "The dual role of endothelial differentiation-related factor-1 in the cytosol and nucleus: modulation by protein kinase A". Cell Mol Life Sci 61 (9): 1069–74. doi:10.1007/s00018-004-4016-0. PMID 15112053.
- ^ a b "Entrez Gene: EDF1 endothelial differentiation-related factor 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8721.
- ^ a b c Brendel, Carole; Gelman Laurent, Auwerx Johan (Jun. 2002). "Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism". Mol. Endocrinol. (United States) 16 (6): 1367–77. doi:10.1210/me.16.6.1367. ISSN 0888-8809. PMID 12040021.
- ^ Mariotti, M; De Benedictis L, Avon E, Maier J A (Aug. 2000). "Interaction between endothelial differentiation-related factor-1 and calmodulin in vitro and in vivo". J. Biol. Chem. (UNITED STATES) 275 (31): 24047–51. doi:10.1074/jbc.M001928200. ISSN 0021-9258. PMID 10816571.
- ^ Kabe, Y; Goto M, Shima D, Imai T, Wada T, Morohashi K i, Shirakawa M, Hirose S, Handa H (Nov. 1999). "The role of human MBF1 as a transcriptional coactivator". J. Biol. Chem. (UNITED STATES) 274 (48): 34196–202. doi:10.1074/jbc.274.48.34196. ISSN 0021-9258. PMID 10567391.
Further reading
- Li FQ, Ueda H, Hirose S (1994). "Mediators of activation of fushi tarazu gene transcription by BmFTZ-F1". Mol. Cell. Biol. 14 (5): 3013–21. PMC 358669. PMID 8164657. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=358669.
- Ozaki J, Takemaru KI, Ikegami T, et al. (1999). "Identification of the core domain and the secondary structure of the transcriptional coactivator MBF1". Genes Cells 4 (7): 415–24. doi:10.1046/j.1365-2443.1999.00267.x. PMID 10469174.
- Kabe Y, Goto M, Shima D, et al. (1999). "The role of human MBF1 as a transcriptional coactivator". J. Biol. Chem. 274 (48): 34196–202. doi:10.1074/jbc.274.48.34196. PMID 10567391.
- Mariotti M, De Benedictis L, Avon E, Maier JA (2000). "Interaction between endothelial differentiation-related factor-1 and calmodulin in vitro and in vivo". J. Biol. Chem. 275 (31): 24047–51. doi:10.1074/jbc.M001928200. PMID 10816571.
- Brendel C, Gelman L, Auwerx J (2003). "Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism". Mol. Endocrinol. 16 (6): 1367–77. doi:10.1210/me.16.6.1367. PMID 12040021.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2734081.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Bolognese F, Pitarque-Martì M, Lo Cicero V, et al. (2006). "Characterization of the human EDF-1 minimal promoter: involvement of NFY and Sp1 in the regulation of basal transcription". Gene 374: 87–95. doi:10.1016/j.gene.2006.01.030. PMID 16567061.
|
PDB gallery
|
|
|
|
1x57: Solution structures of the HTH domain of human EDF-1 protein
|
|
|
|