EDC3

Enhancer of mRNA decapping 3 homolog (S. cerevisiae)

Rendering based on PDB 2VC8.

Available structures
PDB	2VC8, 2WAX, 2WAY, 3D3J, 3D3K

Identifiers

Symbols

EDC3; FLJ21128; FLJ31777; LSM16; YJDC; YJEFN2

External IDs

OMIM: 609842 MGI: 2142951 HomoloGene: 11827 GeneCards: EDC3 Gene

Gene Ontology
Molecular function	• RNA binding • protein binding
Cellular component	• cytoplasmic mRNA processing body • cytoplasm • cytosol
Biological process	• nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay • RNA metabolic process • mRNA metabolic process • exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 15:
74.92 – 74.99 Mb

Chr 9:
57.56 – 57.6 Mb

PubMed search

[1]

[2]

Enhancer of mRNA-decapping protein 3 is a protein that in humans is encoded by the EDC3 gene.^[1]^[2]^[3]

EDC3 is associated with an mRNA-decapping complex required for removal of the 5-prime cap from mRNA prior to its degradation from the 5-prime end (Fenger-Gron et al., 2005).[supplied by OMIM]^[3]

References

^ Albrecht M, Lengauer T (Jun 2004). "Novel Sm-like proteins with long C-terminal tails and associated methyltransferases". FEBS Lett 569 (1–3): 18–26. doi:10.1016/j.febslet.2004.03.126. PMID 15225602.
^ Rudolph C, Sigruener A, Hartmann A, Orso E, Bals-Pratsch M, Gronwald W, Seifert B, Kalbitzer HR, Verdorfer I, Luetjens CM, Ortmann O, Bornstein SR, Schmitz G (May 2007). "ApoA-I-binding protein (AI-BP) and its homologues hYjeF_N2 and hYjeF_N3 comprise the YjeF_N domain protein family in humans with a role in spermiogenesis and oogenesis". Horm Metab Res 39 (5): 322–35. doi:10.1055/s-2007-977699. PMID 17533573.
^ ^a ^b "Entrez Gene: EDC3 enhancer of mRNA decapping 3 homolog (S. cerevisiae)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=80153.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Jin J, Smith FD, Stark C et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Wan D, Gong Y, Qin W et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=524842.
Fenger-Grøn M, Fillman C, Norrild B, Lykke-Andersen J (2006). "Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping". Mol. Cell 20 (6): 905–15. doi:10.1016/j.molcel.2005.10.031. PMID 16364915.
Beausoleil SA, Villén J, Gerber SA et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
Ewing RM, Chu P, Elisma F et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948.
Tritschler F, Eulalio A, Truffault V et al. (2007). "A Divergent Sm Fold in EDC3 Proteins Mediates DCP1 Binding and P-Body Targeting". Mol. Cell. Biol. 27 (24): 8600–11. doi:10.1128/MCB.01506-07. PMC 2169425. PMID 17923697. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2169425.

Post-transcriptional modification

Nuclear	Precursor mRNA · 5' cap formation · Polyadenylation (CPSF, CstF, PAP, PAB2, CFI, CFII) · Poly(A)-binding protein RNA splicing: intron/exon · snRNP · spliceosome (minor spliceosome, U1) · alternative splicing · pre-mRNA processing factor (PLRG1, PRPF3, PRPF4, PRPF4B, PRPF6, PRPF8, PRPF18, PRPF19, PRPF31, PRPF38A, PRPF38B, PRPF39, PRPF40A, PRPF40B) RNA editing · Polyuridylation

Cytosolic	5' cap methylation Messenger RNA decapping: DCP1A · DCP1B · DCP2 · DCPS · EDC3 · EDC4

see also disorders of transcription and post transcriptional modification B bsyn: dna (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°)

EDC3

References

Further reading