| Systematic (IUPAC) name | |
|---|---|
| (4S,4aS,5aS,6S,12aS,Z)-2-[amino(hydroxy)methylene]-7-chloro-4-(dimethylamino)-6,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydrotetracene-1,3,12(2H,4H,12aH)-trione | |
| Clinical data | |
| AHFS/Drugs.com | Micromedex Detailed Consumer Information |
| Pregnancy cat. | ? |
| Legal status | ? |
| Routes | Oral, IV, topical |
| Pharmacokinetic data | |
| Bioavailability | 30% |
| Protein binding | 50 to 55% |
| Metabolism | Hepatic (75%) |
| Half-life | 5.6 to 9 hours |
| Excretion | Renal and biliary |
| Identifiers | |
| CAS number | 57-62-5 |
| ATC code | A01AB21 D06AA02 J01AA03 S01AA02 QJ51AA03 |
| ChemSpider | 10469370 |
| UNII | WCK1KIQ23Q |
| KEGG | D07689 |
| ChEMBL | CHEMBL456066 |
| Chemical data | |
| Formula | C22H23ClN2O8 |
| Mol. mass | 478.88 g/mol |
| SMILES | eMolecules & PubChem |
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Chlortetracycline (trade name Aureomycin, Lederle) is a tetracycline antibiotic, and was the first tetracycline to be identified. It was discovered in 1945 by Dr. Benjamin Duggar working at Lederle Laboratories under the supervision of Dr.Subba Rao . Duggar identified the antibiotic as the product of a actinomycete he cultured from a soil sample collected from Sanborn Field at the University of Missouri.[1] The organism was named Streptomyces aureofaciens and the isolated drug, Aureomycin, because of their golden color.
In veterinary medicine, chlortetracycline is commonly used to treat conjunctivitis in cats.[2]
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