Drebrin-like

PDB rendering based on 1x67.

Available structures
PDB	1x67

Identifiers

Symbols

DBNL; ABP1; HIP-55; SH3P7

External IDs

OMIM: 610106 MGI: 700006 HomoloGene: 8468 GeneCards: DBNL Gene

Gene Ontology
Molecular function	• actin binding • protein binding • enzyme activator activity • identical protein binding
Cellular component	• intracellular • cytoplasm • cytosol • cytoskeleton • cell cortex • lamellipodium
Biological process	• endocytosis • apoptosis • cellular component disassembly involved in apoptosis • activation of JUN kinase activity • Rac protein signal transduction
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 7:
44.08 – 44.11 Mb

Chr 11:
5.69 – 5.7 Mb

PubMed search

[1]

[2]

Drebrin-like protein is a protein that in humans is encoded by the DBNL gene.^[1]^[2]

Interactions

Drebrin-like has been shown to interact with Cyclin-dependent kinase 4,^[3] MAP4K1^[4] and ZAP-70.^[5]

References

^ Lee CG, Morse HC 3rd, Kay BK, Kozak CA (May 1999). "Genetic mapping of eight SH3 domain genes on seven mouse chromosomes". Mamm Genome 10 (4): 402–4. doi:10.1007/s003359901011. PMID 10087302.
^ "Entrez Gene: DBNL drebrin-like". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=28988.
^ Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948.
^ Ensenat, D; Yao Z, Wang X S, Kori R, Zhou G, Lee S C, Tan T H (Nov. 1999). "A novel src homology 3 domain-containing adaptor protein, HIP-55, that interacts with hematopoietic progenitor kinase 1". J. Biol. Chem. (UNITED STATES) 274 (48): 33945–50. doi:10.1074/jbc.274.48.33945. ISSN 0021-9258. PMID 10567356.
^ Han, Jin; Kori Rajashree, Shui Jr-Wen, Chen Yi-Rong, Yao Zhengbin, Tan Tse-Hua (Dec. 2003). "The SH3 domain-containing adaptor HIP-55 mediates c-Jun N-terminal kinase activation in T cell receptor signaling". J. Biol. Chem. (United States) 278 (52): 52195–202. doi:10.1074/jbc.M305026200. ISSN 0021-9258. PMID 14557276.

Gipson IK, Spurr-Michaud S, Moccia R, et al. (1999). "MUC4 and MUC5B transcripts are the prevalent mucin messenger ribonucleic acids of the human endocervix.". Biol. Reprod. 60 (1): 58–64. doi:10.1095/biolreprod60.1.58. PMID 9858486.
Larbolette O, Wollscheid B, Schweikert J, et al. (1999). "SH3P7 is a cytoskeleton adapter protein and is coupled to signal transduction from lymphocyte antigen receptors.". Mol. Cell. Biol. 19 (2): 1539–46. PMC 116082. PMID 9891087. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=116082.
Ensenat D, Yao Z, Wang XS, et al. (1999). "A novel src homology 3 domain-containing adaptor protein, HIP-55, that interacts with hematopoietic progenitor kinase 1.". J. Biol. Chem. 274 (48): 33945–50. doi:10.1074/jbc.274.48.33945. PMID 10567356.
Yamazaki H, Takahashi H, Aoki T, Shirao T (2001). "Molecular cloning and dendritic localization of rat SH3P7.". Eur. J. Neurosci. 14 (6): 998–1008. doi:10.1046/j.0953-816x.2001.01727.x. PMID 11595038.
Chen YR, Kori R, John B, Tan TH (2001). "Caspase-mediated cleavage of actin-binding and SH3-domain-containing proteins cortactin, HS1, and HIP-55 during apoptosis.". Biochem. Biophys. Res. Commun. 288 (4): 981–9. doi:10.1006/bbrc.2001.5862. PMID 11689006.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Mise-Omata S, Montagne B, Deckert M, et al. (2003). "Mammalian actin binding protein 1 is essential for endocytosis but not lamellipodia formation: functional analysis by RNA interference.". Biochem. Biophys. Res. Commun. 301 (3): 704–10. doi:10.1016/S0006-291X(02)02972-8. PMID 12565838.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2882961.
Hou P, Estrada L, Kinley AW, et al. (2004). "Fgd1, the Cdc42 GEF responsible for Faciogenital Dysplasia, directly interacts with cortactin and mAbp1 to modulate cell shape.". Hum. Mol. Genet. 12 (16): 1981–93. doi:10.1093/hmg/ddg209. PMID 12913069.
Han J, Kori R, Shui JW, et al. (2004). "The SH3 domain-containing adaptor HIP-55 mediates c-Jun N-terminal kinase activation in T cell receptor signaling.". J. Biol. Chem. 278 (52): 52195–202. doi:10.1074/jbc.M305026200. PMID 14557276.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Le Bras S, Foucault I, Foussat A, et al. (2004). "Recruitment of the actin-binding protein HIP-55 to the immunological synapse regulates T cell receptor signaling and endocytosis.". J. Biol. Chem. 279 (15): 15550–60. doi:10.1074/jbc.M312659200. PMID 14729663.
Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression.". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=524842.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
Denis FM, Benecke A, Di Gioia Y, et al. (2005). "PRAM-1 potentiates arsenic trioxide-induced JNK activation.". J. Biol. Chem. 280 (10): 9043–8. doi:10.1074/jbc.M413564200. PMID 15637062.
Han J, Shui JW, Zhang X, et al. (2005). "HIP-55 is important for T-cell proliferation, cytokine production, and immune responses.". Mol. Cell. Biol. 25 (16): 6869–78. doi:10.1128/MCB.25.16.6869-6878.2005. PMC 1190228. PMID 16055701. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1190228.
Tao WA, Wollscheid B, O'Brien R, et al. (2005). "Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry.". Nat. Methods 2 (8): 591–8. doi:10.1038/nmeth776. PMID 16094384.

PDB gallery

1x67: Solution structure of the cofilin homology domain of HIP-55 (drebrin-like protein)

Drebrin-like

Interactions

References

Further reading