Doxpicomine
Doxpicomine (Doxpicodin, Doxpizodine) is a mild opioid analgesic drug.[1]. The drug acts as a mu-opioid receptor agonist.[2] It is of fairly low potency, with a 400 mg dose of doxpicomine approximately equivalent in pain-killing effect to 8 mg morphine or 100 mg pethidine.[3][4] It has been used as a lead compound to derive further analogues, although all compounds in this family are comparatively weak mu agonists.[5]
References
- ^ US 3905987, Booher, R.N., "m-Dioxane-5-Methylamine Analgesics", issued 09/16/1975, assigned to Eli Lilly
- ^ Smits, S. E.; Nickander, R.; Booher, R. N.; Zimmerman, D. M.; Wong, D. T.; Hynes, M. D.; Pohland, A. (1981). "Preclinical pharmacology of doxpicodin, a new analgesic". NIDA research monograph 34: 75–81. PMID 6261137. edit
- ^ Wang, R. I.; Robinson, N. (1981). "Doxpicomine in postoperative pain". Clinical pharmacology and therapeutics 29 (6): 771–775. doi:10.1038/clpt.1981.109. PMID 7014073. edit
- ^ Wang, R. I.; Robinson, N. (1983). "Further efficacy evaluation of doxpicomine for postoperative pain". Journal of clinical pharmacology 23 (1): 44–47. PMID 6341416. edit
- ^ Wünsch, B.; Bauschke, G. (1993). "Benzomorphan analogs with doxpicomine partial structure: synthesis and psychopharmacologic investigations of 5-aminomethyl- and 5-(alpha-aminobenzyl)- substituted 2,6-epoxy-3-benzoxocines". Archiv der Pharmazie 326 (3): 171–180. PMID 8481096. edit
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