Dihydromethysticin

Dihydromethysticin

IUPAC name (2S)-2-[2-(1,3-benzodioxol-5-yl)ethyl]-4-methoxy-2,3-dihydropyran-6-one
Identifiers
CAS number	19902-91-1
PubChem	88308
Jmol-3D images	Image 1
SMILES COC1=CC(=O)OC(C1)CCC2=CC3=C(C=C2)OCO3
Properties
Molecular formula	C₁₅H₁₆O₅
Molar mass	276.28 g/mol
Exact mass	276.099774 u
Y (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Dihydromethysticin is one of the six major kavalactones found in the kava plant.^[1]

Pharmacology

Dihydromethysticin has marked activity on the induction of CYP3A23.^[2]

^ Malani, Joji (2002-12-03). "Evaluation of the effects of Kava on the Liver". Fiji School of Medicine. http://www.spc.int/cis/documents/Kava%20article%20DrMalani.pdf. Retrieved 2009-09-04.
^ Ma, Yuzhong; Karuna Sachdeva, Jirong Liu1, Michael Ford, Dongfang Yang, Ikhlas Khan, Clinton Chichester, Bingfang Yan (2004 November). "Desmethoxyyangonin and dihydromethysticin are two major pharmacological kavalactones with marked activity on the induction of CYP3A23.". Drug Metabolism and Disposition 32 (11): 1317–1324. doi:10.1124/dmd.104.000786. PMID 15282211.