Dicycloverine

Dicycloverine
Systematic (IUPAC) name
2-(diethylamino)ethyl bi(cyclohexane)-1-carboxylate
Clinical data
Trade names Byclomine, Bentyl, Dibent, Di-Spaz, Dilomine
AHFS/Drugs.com International Drug Names
MedlinePlus a684007
Pregnancy cat. B(US)
Legal status  ?
Pharmacokinetic data
Protein binding >99%
Half-life 5 h
Identifiers
CAS number 77-19-0 Y
ATC code A03AA07
PubChem CID 3042
IUPHAR ligand 355
DrugBank APRD00113
ChemSpider 2934 Y
UNII 4KV4X8IF6V Y
KEGG D07820 Y
ChEBI CHEBI:4514 Y
ChEMBL CHEMBL1123 Y
Chemical data
Formula C19H35NO2 
Mol. mass 309.487 g/mol
SMILES eMolecules & PubChem
 N(what is this?)  (verify)

Dicyclomine, also known as dicycloverine, is an anticholinergic that blocks muscarinic receptors. Dicycloverine was first synthesized in the United States circa 1947.

Contents

Medical uses

Dicyclomine is used to treat intestinal hypermotility, the symptoms of Irritable Bowel Syndrome (IBS) (also known as spastic colon). It relieves muscle spasms and cramping in the gastrointestinal tract by blocking the activity of acetylcholine on cholinergic (or muscarinic) receptors on the surface of muscle cells. It is a smooth muscle relaxant.[1]

It is sold under various trade names.[2]

In the UK it is ingredient of a multi-ingredient preparation, together with an antiflatulent (simethicone) and two antacids, under the trade name Kolanticon.

Side effects

Dicyclomine can cause a range of anticholinergic side effects such as dry mouth, nausea and at higher doses, deliriant effects.[1] Recreational use of this drug for its anticholinergic effects has been rarely reported.[1][3]

Caution

Breastfeeding is not recommended while using this drug. Users should use care when operating vehicles and/or dangerous machines.[1]

References

  1. ^ a b c d "Dicyclomine hydrochloride". Monograph. Drugs.com. http://www.drugs.com/monograph/dicyclomine-hydrochloride.html. 
  2. ^ "Dicycloverine". International drug names. Drugs.com. http://www.drugs.com/international/dicycloverine.html. 
  3. ^ Carlini E. A. (1993). "Preliminary note: dangerous use of anticholinergic drugs in Brazil". Drug and Alcohol Dependence 32 (1): 1–7. doi:10.1016/0376-8716(93)90016-J. PMID 8486081. 

Notes

External links

Drugs for
functional bowel disorders
Tertiary
amino group
Oxyphencyclimine • Camylofin • Mebeverine • Trimebutine • Rociverine • Dicycloverine • Dihexyverine • Difemerine • Piperidolate
Other
Belladonna and derivatives
(antimuscarinics)

tertiary amines: Atropine • Hyoscyamine

quaternary ammonium compounds: Scopolamine (Butylscopolamine, Methylscopolamine) • Methylatropine • Fentonium • Cimetropium bromide
Propulsives

M: DIG

anat(t, g, p)/phys/devp/enzy

noco/cong/tumr, sysi/epon

proc, drug(A2A/2B/3/4/5/6/7/14/16), blte