Desmoglein

The desmogleins are a family of cadherins consisting of proteins DSG1, DSG2, DSG3, and DSG4. They play a role in the formation of desmosomes that join cells to one another.

Pathology

Desmogleins are targeted in the autoimmune disease pemphigus.[1][2][3]

References

  1. ^ Waschke J, Bruggeman P, Baumgartner W, Zillikens D, Drenckhahn D (November 2005). "Pemphigus foliaceus IgG causes dissociation of desmoglein 1–containing junctions without blocking desmoglein 1 transinteraction". J. Clin. Invest. 115 (11): 3157–65. doi:10.1172/JCI23475. PMC 1242188. PMID 16211092. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1242188. 
  2. ^ Kljuic A, Bazzi H, Sundberg JP, et al. (April 2003). "Desmoglein 4 in hair follicle differentiation and epidermal adhesion: evidence from inherited hypotrichosis and acquired pemphigus vulgaris". Cell 113 (2): 249–60. doi:10.1016/S0092-8674(03)00273-3. PMID 12705872. http://linkinghub.elsevier.com/retrieve/pii/S0092867403002733. 
  3. ^ Müller R, Heber B, Hashimoto T, et al. (May 2009). "Autoantibodies against desmocollins in European patients with pemphigus". Clin. Exp. Dermatol. 34 (8): 898–903. doi:10.1111/j.1365-2230.2009.03241.x. PMID 19456767. 

External links

Calcium-independent
Calcium-dependent
Classical
CDH1 · CDH2 · CDH3
Desmoglein (DSG1, DSG2, DSG3, DSG4) · Desmocollin (DSC1, DSC2, DSC3)
Unconventional/ungrouped
T-cadherin · CDH4 · CDH5 · CDH6 · CDH8 · CDH11 · CDH12 · CDH15 · CDH16 · CDH17 · CDH9 · CDH10
Other
see also cell membrane protein disorders
B memb: cead, trns (1A, 1C, 1F, 2A, 3A1, 3A2-3, 3D), othr
Lateral/cell-cell
Basal/cell-matrix
Apical
B strc: edmb (perx), skel (ctrs), epit, cili, mito, nucl (chro)